Shifts in the selectivity filter dynamics cause modal gating in K+ channels

Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dyn...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shehrazade Jekhmane, João Medeiros-Silva, Jing Li, Felix Kümmerer, Christoph Müller-Hermes, Marc Baldus, Benoît Roux, Markus Weingarth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4666bccf84aa4230955d529c44e30403
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4666bccf84aa4230955d529c44e30403
record_format	dspace
spelling	oai:doaj.org-article:4666bccf84aa4230955d529c44e304032021-12-02T15:35:12ZShifts in the selectivity filter dynamics cause modal gating in K+ channels10.1038/s41467-018-07973-62041-1723https://doaj.org/article/4666bccf84aa4230955d529c44e304032019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07973-6https://doaj.org/toc/2041-1723Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dynamics which perturb the selectivity filter.Shehrazade JekhmaneJoão Medeiros-SilvaJing LiFelix KümmererChristoph Müller-HermesMarc BaldusBenoît RouxMarkus WeingarthNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shehrazade Jekhmane João Medeiros-Silva Jing Li Felix Kümmerer Christoph Müller-Hermes Marc Baldus Benoît Roux Markus Weingarth Shifts in the selectivity filter dynamics cause modal gating in K+ channels
description	Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dynamics which perturb the selectivity filter.
format	article
author	Shehrazade Jekhmane João Medeiros-Silva Jing Li Felix Kümmerer Christoph Müller-Hermes Marc Baldus Benoît Roux Markus Weingarth
author_facet	Shehrazade Jekhmane João Medeiros-Silva Jing Li Felix Kümmerer Christoph Müller-Hermes Marc Baldus Benoît Roux Markus Weingarth
author_sort	Shehrazade Jekhmane
title	Shifts in the selectivity filter dynamics cause modal gating in K+ channels
title_short	Shifts in the selectivity filter dynamics cause modal gating in K+ channels
title_full	Shifts in the selectivity filter dynamics cause modal gating in K+ channels
title_fullStr	Shifts in the selectivity filter dynamics cause modal gating in K+ channels
title_full_unstemmed	Shifts in the selectivity filter dynamics cause modal gating in K+ channels
title_sort	shifts in the selectivity filter dynamics cause modal gating in k+ channels
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4666bccf84aa4230955d529c44e30403
work_keys_str_mv	AT shehrazadejekhmane shiftsintheselectivityfilterdynamicscausemodalgatinginkchannels AT joaomedeirossilva shiftsintheselectivityfilterdynamicscausemodalgatinginkchannels AT jingli shiftsintheselectivityfilterdynamicscausemodalgatinginkchannels AT felixkummerer shiftsintheselectivityfilterdynamicscausemodalgatinginkchannels AT christophmullerhermes shiftsintheselectivityfilterdynamicscausemodalgatinginkchannels AT marcbaldus shiftsintheselectivityfilterdynamicscausemodalgatinginkchannels AT benoitroux shiftsintheselectivityfilterdynamicscausemodalgatinginkchannels AT markusweingarth shiftsintheselectivityfilterdynamicscausemodalgatinginkchannels
_version_	1718386592672907264

Shifts in the selectivity filter dynamics cause modal gating in K+ channels

Ejemplares similares