Shifts in the selectivity filter dynamics cause modal gating in K+ channels

Shifts in the selectivity filter dynamics cause modal gating in K+ channels

Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dyn...

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Autores principales: Shehrazade Jekhmane, João Medeiros-Silva, Jing Li, Felix Kümmerer, Christoph Müller-Hermes, Marc Baldus, Benoît Roux, Markus Weingarth
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/4666bccf84aa4230955d529c44e30403
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