Shifts in the selectivity filter dynamics cause modal gating in K+ channels
Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dyn...
Enregistré dans:
Auteurs principaux: | Shehrazade Jekhmane, João Medeiros-Silva, Jing Li, Felix Kümmerer, Christoph Müller-Hermes, Marc Baldus, Benoît Roux, Markus Weingarth |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2019
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/4666bccf84aa4230955d529c44e30403 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
High-resolution NMR studies of antibiotics in cellular membranes
par: João Medeiros-Silva, et autres
Publié: (2018) -
Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling
par: Wojciech Kopec, et autres
Publié: (2019) -
Gating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter.
par: Leandro Zúñiga, et autres
Publié: (2011) -
Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel
par: Xiafei Yu, et autres
Publié: (2021) -
Expression and relevance of the G protein-gated K+ channel in the mouse ventricle
par: Allison Anderson, et autres
Publié: (2018)