The Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD), a progressive respiratory disease, is characterized by the alveolar epithelium injury and persistent airway inflammation. It is documented that oscillation and dysregulated expression of circadian clock genes, like Bmal1, Per1, and Per2, involved in COPD...

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Autores principales: Yuedi Hu, Tiantian He, Jie Zhu, Xiaole Wang, Jiabing Tong, Zegeng Li, Jingcheng Dong
Formato: article
Lenguaje:EN
Publicado: Hindawi Limited 2021
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Acceso en línea:https://doaj.org/article/466b98e2b1c54a3aa36490d5192c56d0
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spelling oai:doaj.org-article:466b98e2b1c54a3aa36490d5192c56d02021-11-08T02:36:46ZThe Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease1466-186110.1155/2021/2689600https://doaj.org/article/466b98e2b1c54a3aa36490d5192c56d02021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2689600https://doaj.org/toc/1466-1861Chronic obstructive pulmonary disease (COPD), a progressive respiratory disease, is characterized by the alveolar epithelium injury and persistent airway inflammation. It is documented that oscillation and dysregulated expression of circadian clock genes, like Bmal1, Per1, and Per2, involved in COPD pathogenies, including chronic inflammation and imbalanced autophagy level, and targeting the associations of circadian rhythm and autophagy is promising strategies in the management and treatment of COPD. Herein, we reviewed the mechanisms of the circadian clock and the unbalance of the autophagic level in COPD, as well as the link between the two, so as to provide further theoretical bases for the study on the pathogenesis of COPD.Yuedi HuTiantian HeJie ZhuXiaole WangJiabing TongZegeng LiJingcheng DongHindawi LimitedarticlePathologyRB1-214ENMediators of Inflammation, Vol 2021 (2021)
institution DOAJ
collection DOAJ
language EN
topic Pathology
RB1-214
spellingShingle Pathology
RB1-214
Yuedi Hu
Tiantian He
Jie Zhu
Xiaole Wang
Jiabing Tong
Zegeng Li
Jingcheng Dong
The Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease
description Chronic obstructive pulmonary disease (COPD), a progressive respiratory disease, is characterized by the alveolar epithelium injury and persistent airway inflammation. It is documented that oscillation and dysregulated expression of circadian clock genes, like Bmal1, Per1, and Per2, involved in COPD pathogenies, including chronic inflammation and imbalanced autophagy level, and targeting the associations of circadian rhythm and autophagy is promising strategies in the management and treatment of COPD. Herein, we reviewed the mechanisms of the circadian clock and the unbalance of the autophagic level in COPD, as well as the link between the two, so as to provide further theoretical bases for the study on the pathogenesis of COPD.
format article
author Yuedi Hu
Tiantian He
Jie Zhu
Xiaole Wang
Jiabing Tong
Zegeng Li
Jingcheng Dong
author_facet Yuedi Hu
Tiantian He
Jie Zhu
Xiaole Wang
Jiabing Tong
Zegeng Li
Jingcheng Dong
author_sort Yuedi Hu
title The Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease
title_short The Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease
title_full The Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease
title_fullStr The Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease
title_full_unstemmed The Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease
title_sort link between circadian clock genes and autophagy in chronic obstructive pulmonary disease
publisher Hindawi Limited
publishDate 2021
url https://doaj.org/article/466b98e2b1c54a3aa36490d5192c56d0
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