Performance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women

Background. It is known that menopausal women suffer from sleep disorders. As additional diagnostic methods, it is possible to use the equations of linear classification functions.Aim: to determine the most informative parameters among the lipid profile, the “lipid peroxidation – antioxidant protect...

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Autores principales:	N. V. Semenova, I. M. Madaeva, I. M. Mikhalevich, L. I. Kolesnikova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	sleep disorders climacteric discriminant analysis Science Q
Acceso en línea:	https://doaj.org/article/467374370f8c4db0b2211e94871c84f3
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spelling	oai:doaj.org-article:467374370f8c4db0b2211e94871c84f32021-11-23T06:14:41ZPerformance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women2541-94202587-959610.29413/ABS.2018-3.6.1https://doaj.org/article/467374370f8c4db0b2211e94871c84f32019-01-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1875https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. It is known that menopausal women suffer from sleep disorders. As additional diagnostic methods, it is possible to use the equations of linear classification functions.Aim: to determine the most informative parameters among the lipid profile, the “lipid peroxidation – antioxidant protection” system parameters and the melatonin secretion chronobiological rhythms in menopausal women with sleep disorders.Materials and methods. 56 perimenopausal women and 70 postmenopausal ones in accordance with the inclusion criteria participated in this study. Diagnoses of insomnia and obstructive sleep apnea syndrome were made according to the results of specialized somnological questionnaires and polysomnographic monitoring. Spectrophotometric methods for studying of lipid metabolism and the “lipid peroxidation – antioxidant protection” system parameters, an enzyme immunoassay method for determining melatonin were also used. A multidimensional discriminant analysis to reveal the most informative parameters among the parameters studied was used.Results. The most informative indicators of the metabolic system for sleep disorders in perimenopausal women with insomnia are melatonin 06.00–07.00 h, melatonin 18.00–19.00 h, melatonin 23.00–00.00 h, ketodienes and conjugated trienes, oxidized glutathione; with insomnia and OSAS – melatonin 06.00–07.00 h, melatonin 12.00–13.00 h, melatonin 23.00–00.00 h, substrates with conjugated double bonds, total cholesterol; in postmenopausal women with insomnia – diene conjugates, α-tocopherol, total antioxidant capacity, active products of thiobarbituric acid, reduced glutathione; with insomnia and OSAS – total antioxidant capacity, α-tocopherol, substrates with conjugated double bonds.Conclusions. The results obtained indicate a great strain in the antioxidant protection system in menopausal women with sleep disorders in response to changes in free radical homeostasis.N. V. SemenovaI. M. MadaevaI. M. MikhalevichL. I. KolesnikovaScientific Сentre for Family Health and Human Reproduction Problemsarticlesleep disordersclimactericdiscriminant analysisScienceQRUActa Biomedica Scientifica, Vol 3, Iss 6, Pp 9-14 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	sleep disorders climacteric discriminant analysis Science Q
spellingShingle	sleep disorders climacteric discriminant analysis Science Q N. V. Semenova I. M. Madaeva I. M. Mikhalevich L. I. Kolesnikova Performance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women
description	Background. It is known that menopausal women suffer from sleep disorders. As additional diagnostic methods, it is possible to use the equations of linear classification functions.Aim: to determine the most informative parameters among the lipid profile, the “lipid peroxidation – antioxidant protection” system parameters and the melatonin secretion chronobiological rhythms in menopausal women with sleep disorders.Materials and methods. 56 perimenopausal women and 70 postmenopausal ones in accordance with the inclusion criteria participated in this study. Diagnoses of insomnia and obstructive sleep apnea syndrome were made according to the results of specialized somnological questionnaires and polysomnographic monitoring. Spectrophotometric methods for studying of lipid metabolism and the “lipid peroxidation – antioxidant protection” system parameters, an enzyme immunoassay method for determining melatonin were also used. A multidimensional discriminant analysis to reveal the most informative parameters among the parameters studied was used.Results. The most informative indicators of the metabolic system for sleep disorders in perimenopausal women with insomnia are melatonin 06.00–07.00 h, melatonin 18.00–19.00 h, melatonin 23.00–00.00 h, ketodienes and conjugated trienes, oxidized glutathione; with insomnia and OSAS – melatonin 06.00–07.00 h, melatonin 12.00–13.00 h, melatonin 23.00–00.00 h, substrates with conjugated double bonds, total cholesterol; in postmenopausal women with insomnia – diene conjugates, α-tocopherol, total antioxidant capacity, active products of thiobarbituric acid, reduced glutathione; with insomnia and OSAS – total antioxidant capacity, α-tocopherol, substrates with conjugated double bonds.Conclusions. The results obtained indicate a great strain in the antioxidant protection system in menopausal women with sleep disorders in response to changes in free radical homeostasis.
format	article
author	N. V. Semenova I. M. Madaeva I. M. Mikhalevich L. I. Kolesnikova
author_facet	N. V. Semenova I. M. Madaeva I. M. Mikhalevich L. I. Kolesnikova
author_sort	N. V. Semenova
title	Performance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women
title_short	Performance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women
title_full	Performance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women
title_fullStr	Performance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women
title_full_unstemmed	Performance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women
title_sort	performance of metabolic parameters in formation of sleep disorders in menopausal women
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/467374370f8c4db0b2211e94871c84f3
work_keys_str_mv	AT nvsemenova performanceofmetabolicparametersinformationofsleepdisordersinmenopausalwomen AT immadaeva performanceofmetabolicparametersinformationofsleepdisordersinmenopausalwomen AT immikhalevich performanceofmetabolicparametersinformationofsleepdisordersinmenopausalwomen AT likolesnikova performanceofmetabolicparametersinformationofsleepdisordersinmenopausalwomen
_version_	1718416939716444160

Performance of Metabolic Parameters in Formation of Sleep Disorders in Menopausal Women

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