Molecular estimation of neurodegeneration pseudotime in older brains

The limited understanding of the temporal molecular changes in late-onset Alzheimer’s disease hinder the development of therapeutic treatment. The authors use manifold learning to develop a molecular model for disease progression from RNASeq data from human postmortem brain samples.

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Autores principales:	Sumit Mukherjee, Laura Heath, Christoph Preuss, Suman Jayadev, Gwenn A. Garden, Anna K. Greenwood, Solveig K. Sieberts, Philip L. De Jager, Nilüfer Ertekin-Taner, Gregory W. Carter, Lara M. Mangravite, Benjamin A. Logsdon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/467434a5e4e8458aa4f2642bf2e3f186
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spelling	oai:doaj.org-article:467434a5e4e8458aa4f2642bf2e3f1862021-12-02T15:37:12ZMolecular estimation of neurodegeneration pseudotime in older brains10.1038/s41467-020-19622-y2041-1723https://doaj.org/article/467434a5e4e8458aa4f2642bf2e3f1862020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19622-yhttps://doaj.org/toc/2041-1723The limited understanding of the temporal molecular changes in late-onset Alzheimer’s disease hinder the development of therapeutic treatment. The authors use manifold learning to develop a molecular model for disease progression from RNASeq data from human postmortem brain samples.Sumit MukherjeeLaura HeathChristoph PreussSuman JayadevGwenn A. GardenAnna K. GreenwoodSolveig K. SiebertsPhilip L. De JagerNilüfer Ertekin-TanerGregory W. CarterLara M. MangraviteBenjamin A. LogsdonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sumit Mukherjee Laura Heath Christoph Preuss Suman Jayadev Gwenn A. Garden Anna K. Greenwood Solveig K. Sieberts Philip L. De Jager Nilüfer Ertekin-Taner Gregory W. Carter Lara M. Mangravite Benjamin A. Logsdon Molecular estimation of neurodegeneration pseudotime in older brains
description	The limited understanding of the temporal molecular changes in late-onset Alzheimer’s disease hinder the development of therapeutic treatment. The authors use manifold learning to develop a molecular model for disease progression from RNASeq data from human postmortem brain samples.
format	article
author	Sumit Mukherjee Laura Heath Christoph Preuss Suman Jayadev Gwenn A. Garden Anna K. Greenwood Solveig K. Sieberts Philip L. De Jager Nilüfer Ertekin-Taner Gregory W. Carter Lara M. Mangravite Benjamin A. Logsdon
author_facet	Sumit Mukherjee Laura Heath Christoph Preuss Suman Jayadev Gwenn A. Garden Anna K. Greenwood Solveig K. Sieberts Philip L. De Jager Nilüfer Ertekin-Taner Gregory W. Carter Lara M. Mangravite Benjamin A. Logsdon
author_sort	Sumit Mukherjee
title	Molecular estimation of neurodegeneration pseudotime in older brains
title_short	Molecular estimation of neurodegeneration pseudotime in older brains
title_full	Molecular estimation of neurodegeneration pseudotime in older brains
title_fullStr	Molecular estimation of neurodegeneration pseudotime in older brains
title_full_unstemmed	Molecular estimation of neurodegeneration pseudotime in older brains
title_sort	molecular estimation of neurodegeneration pseudotime in older brains
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/467434a5e4e8458aa4f2642bf2e3f186
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Molecular estimation of neurodegeneration pseudotime in older brains

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