The sexually antagonistic genes of Drosophila melanogaster.

When selective pressures differ between males and females, the genes experiencing these conflicting evolutionary forces are said to be sexually antagonistic. Although the phenotypic effect of these genes has been documented in both wild and laboratory populations, their identity, number, and locatio...

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Autores principales:	Paolo Innocenti, Edward H Morrow
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4678c7f21f4144fd9557264ccf4f1971
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id	oai:doaj.org-article:4678c7f21f4144fd9557264ccf4f1971
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spelling	oai:doaj.org-article:4678c7f21f4144fd9557264ccf4f19712021-11-25T05:34:20ZThe sexually antagonistic genes of Drosophila melanogaster.1544-91731545-788510.1371/journal.pbio.1000335https://doaj.org/article/4678c7f21f4144fd9557264ccf4f19712010-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20305719/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885When selective pressures differ between males and females, the genes experiencing these conflicting evolutionary forces are said to be sexually antagonistic. Although the phenotypic effect of these genes has been documented in both wild and laboratory populations, their identity, number, and location remains unknown. Here, by combining data on sex-specific fitness and genome-wide transcript abundance in a quantitative genetic framework, we identified a group of candidate genes experiencing sexually antagonistic selection in the adult, which correspond to 8% of Drosophila melanogaster genes. As predicted, the X chromosome is enriched for these genes, but surprisingly they represent only a small proportion of the total number of sex-biased transcripts, indicating that the latter is a poor predictor of sexual antagonism. Furthermore, the majority of genes whose expression profiles showed a significant relationship with either male or female adult fitness are also sexually antagonistic. These results provide a first insight into the genetic basis of intralocus sexual conflict and indicate that genetic variation for fitness is dominated and maintained by sexual antagonism, potentially neutralizing any indirect genetic benefits of sexual selection.Paolo InnocentiEdward H MorrowPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 8, Iss 3, p e1000335 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Paolo Innocenti Edward H Morrow The sexually antagonistic genes of Drosophila melanogaster.
description	When selective pressures differ between males and females, the genes experiencing these conflicting evolutionary forces are said to be sexually antagonistic. Although the phenotypic effect of these genes has been documented in both wild and laboratory populations, their identity, number, and location remains unknown. Here, by combining data on sex-specific fitness and genome-wide transcript abundance in a quantitative genetic framework, we identified a group of candidate genes experiencing sexually antagonistic selection in the adult, which correspond to 8% of Drosophila melanogaster genes. As predicted, the X chromosome is enriched for these genes, but surprisingly they represent only a small proportion of the total number of sex-biased transcripts, indicating that the latter is a poor predictor of sexual antagonism. Furthermore, the majority of genes whose expression profiles showed a significant relationship with either male or female adult fitness are also sexually antagonistic. These results provide a first insight into the genetic basis of intralocus sexual conflict and indicate that genetic variation for fitness is dominated and maintained by sexual antagonism, potentially neutralizing any indirect genetic benefits of sexual selection.
format	article
author	Paolo Innocenti Edward H Morrow
author_facet	Paolo Innocenti Edward H Morrow
author_sort	Paolo Innocenti
title	The sexually antagonistic genes of Drosophila melanogaster.
title_short	The sexually antagonistic genes of Drosophila melanogaster.
title_full	The sexually antagonistic genes of Drosophila melanogaster.
title_fullStr	The sexually antagonistic genes of Drosophila melanogaster.
title_full_unstemmed	The sexually antagonistic genes of Drosophila melanogaster.
title_sort	sexually antagonistic genes of drosophila melanogaster.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/4678c7f21f4144fd9557264ccf4f1971
work_keys_str_mv	AT paoloinnocenti thesexuallyantagonisticgenesofdrosophilamelanogaster AT edwardhmorrow thesexuallyantagonisticgenesofdrosophilamelanogaster AT paoloinnocenti sexuallyantagonisticgenesofdrosophilamelanogaster AT edwardhmorrow sexuallyantagonisticgenesofdrosophilamelanogaster
_version_	1718414574060830720

The sexually antagonistic genes of Drosophila melanogaster.

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