MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders

The mesencephalic astrocyte-derived neurotrophic factor (MANF), also named as arginine-rich protein (ARP) or arginine-rich mutated in early-stage tumors (ARMET), is a novel evolutionary conserved protein related to unfolded protein response. Growing evidence suggests that MANF critically involves in...

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Autores principales:	Yang Yu, Dan-yang Liu, Xue-shen Chen, Ling Zhu, Li-hong Wan
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/467ce5fd601145f090d62bc25d9856fa
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spelling	oai:doaj.org-article:467ce5fd601145f090d62bc25d9856fa2021-11-08T02:36:52ZMANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders1942-099410.1155/2021/6467679https://doaj.org/article/467ce5fd601145f090d62bc25d9856fa2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6467679https://doaj.org/toc/1942-0994The mesencephalic astrocyte-derived neurotrophic factor (MANF), also named as arginine-rich protein (ARP) or arginine-rich mutated in early-stage tumors (ARMET), is a novel evolutionary conserved protein related to unfolded protein response. Growing evidence suggests that MANF critically involves in many ER stress-related diseases with a protective effect. Here, we review the function of MANF based on its structure in neurological and metabolic disorders and summarize its potential applications in disease diagnosis and therapies.Yang YuDan-yang LiuXue-shen ChenLing ZhuLi-hong WanHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Yang Yu Dan-yang Liu Xue-shen Chen Ling Zhu Li-hong Wan MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
description	The mesencephalic astrocyte-derived neurotrophic factor (MANF), also named as arginine-rich protein (ARP) or arginine-rich mutated in early-stage tumors (ARMET), is a novel evolutionary conserved protein related to unfolded protein response. Growing evidence suggests that MANF critically involves in many ER stress-related diseases with a protective effect. Here, we review the function of MANF based on its structure in neurological and metabolic disorders and summarize its potential applications in disease diagnosis and therapies.
format	article
author	Yang Yu Dan-yang Liu Xue-shen Chen Ling Zhu Li-hong Wan
author_facet	Yang Yu Dan-yang Liu Xue-shen Chen Ling Zhu Li-hong Wan
author_sort	Yang Yu
title	MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
title_short	MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
title_full	MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
title_fullStr	MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
title_full_unstemmed	MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders
title_sort	manf: a novel endoplasmic reticulum stress response protein—the role in neurological and metabolic disorders
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/467ce5fd601145f090d62bc25d9856fa
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MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders

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