Architecture of a SARS-CoV-2 mini replication and transcription complex

SARS-CoV-2 virus replication and transcription is mediated by the replication and transcription complex (RTC) that is composed of 16 non-structural proteins (nsp). Here, the authors present the cryo-EM structure of a SARS-CoV-2 mini RTC consisting of the viral RNA-dependent RNA polymerase with a tem...

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Autores principales:	Liming Yan, Ying Zhang, Ji Ge, Litao Zheng, Yan Gao, Tao Wang, Zhihui Jia, Haofeng Wang, Yucen Huang, Mingyu Li, Quan Wang, Zihe Rao, Zhiyong Lou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/467d5f7c7cea4eaf9904bb9cce1404cd
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spelling	oai:doaj.org-article:467d5f7c7cea4eaf9904bb9cce1404cd2021-12-02T17:31:23ZArchitecture of a SARS-CoV-2 mini replication and transcription complex10.1038/s41467-020-19770-12041-1723https://doaj.org/article/467d5f7c7cea4eaf9904bb9cce1404cd2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19770-1https://doaj.org/toc/2041-1723SARS-CoV-2 virus replication and transcription is mediated by the replication and transcription complex (RTC) that is composed of 16 non-structural proteins (nsp). Here, the authors present the cryo-EM structure of a SARS-CoV-2 mini RTC consisting of the viral RNA-dependent RNA polymerase with a template-primer RNA, the RdRp cofactors nsp7 and nsp8 and two nsp13 helicase molecules, and they propose a model for helicase-polymerase coupling during SARS-CoV-2 RTC assembly.Liming YanYing ZhangJi GeLitao ZhengYan GaoTao WangZhihui JiaHaofeng WangYucen HuangMingyu LiQuan WangZihe RaoZhiyong LouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liming Yan Ying Zhang Ji Ge Litao Zheng Yan Gao Tao Wang Zhihui Jia Haofeng Wang Yucen Huang Mingyu Li Quan Wang Zihe Rao Zhiyong Lou Architecture of a SARS-CoV-2 mini replication and transcription complex
description	SARS-CoV-2 virus replication and transcription is mediated by the replication and transcription complex (RTC) that is composed of 16 non-structural proteins (nsp). Here, the authors present the cryo-EM structure of a SARS-CoV-2 mini RTC consisting of the viral RNA-dependent RNA polymerase with a template-primer RNA, the RdRp cofactors nsp7 and nsp8 and two nsp13 helicase molecules, and they propose a model for helicase-polymerase coupling during SARS-CoV-2 RTC assembly.
format	article
author	Liming Yan Ying Zhang Ji Ge Litao Zheng Yan Gao Tao Wang Zhihui Jia Haofeng Wang Yucen Huang Mingyu Li Quan Wang Zihe Rao Zhiyong Lou
author_facet	Liming Yan Ying Zhang Ji Ge Litao Zheng Yan Gao Tao Wang Zhihui Jia Haofeng Wang Yucen Huang Mingyu Li Quan Wang Zihe Rao Zhiyong Lou
author_sort	Liming Yan
title	Architecture of a SARS-CoV-2 mini replication and transcription complex
title_short	Architecture of a SARS-CoV-2 mini replication and transcription complex
title_full	Architecture of a SARS-CoV-2 mini replication and transcription complex
title_fullStr	Architecture of a SARS-CoV-2 mini replication and transcription complex
title_full_unstemmed	Architecture of a SARS-CoV-2 mini replication and transcription complex
title_sort	architecture of a sars-cov-2 mini replication and transcription complex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/467d5f7c7cea4eaf9904bb9cce1404cd
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Architecture of a SARS-CoV-2 mini replication and transcription complex

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