Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody

Here, using the K18-hACE2 transgenic mice model, the authors report the in vivo efficacy of a fully human neutralizing antibody against SARS-CoV-2 and show that when administered before or up to 3 days post infection, treated mice do not exhibit disease symptoms while 80% of control animals succumb...

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Autores principales:	Ronit Rosenfeld, Tal Noy-Porat, Adva Mechaly, Efi Makdasi, Yinon Levy, Ron Alcalay, Reut Falach, Moshe Aftalion, Eyal Epstein, David Gur, Theodor Chitlaru, Einat B. Vitner, Sharon Melamed, Boaz Politi, Ayelet Zauberman, Shirley Lazar, Adi Beth-Din, Yentl Evgy, Shmuel Yitzhaki, Shmuel C. Shapira, Tomer Israely, Ohad Mazor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/46809b3d714542f1b041f07ea3d49be0
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spelling	oai:doaj.org-article:46809b3d714542f1b041f07ea3d49be02021-12-02T14:26:44ZPost-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody10.1038/s41467-021-21239-82041-1723https://doaj.org/article/46809b3d714542f1b041f07ea3d49be02021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21239-8https://doaj.org/toc/2041-1723Here, using the K18-hACE2 transgenic mice model, the authors report the in vivo efficacy of a fully human neutralizing antibody against SARS-CoV-2 and show that when administered before or up to 3 days post infection, treated mice do not exhibit disease symptoms while 80% of control animals succumb to the infection.Ronit RosenfeldTal Noy-PoratAdva MechalyEfi MakdasiYinon LevyRon AlcalayReut FalachMoshe AftalionEyal EpsteinDavid GurTheodor ChitlaruEinat B. VitnerSharon MelamedBoaz PolitiAyelet ZaubermanShirley LazarAdi Beth-DinYentl EvgyShmuel YitzhakiShmuel C. ShapiraTomer IsraelyOhad MazorNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ronit Rosenfeld Tal Noy-Porat Adva Mechaly Efi Makdasi Yinon Levy Ron Alcalay Reut Falach Moshe Aftalion Eyal Epstein David Gur Theodor Chitlaru Einat B. Vitner Sharon Melamed Boaz Politi Ayelet Zauberman Shirley Lazar Adi Beth-Din Yentl Evgy Shmuel Yitzhaki Shmuel C. Shapira Tomer Israely Ohad Mazor Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
description	Here, using the K18-hACE2 transgenic mice model, the authors report the in vivo efficacy of a fully human neutralizing antibody against SARS-CoV-2 and show that when administered before or up to 3 days post infection, treated mice do not exhibit disease symptoms while 80% of control animals succumb to the infection.
format	article
author	Ronit Rosenfeld Tal Noy-Porat Adva Mechaly Efi Makdasi Yinon Levy Ron Alcalay Reut Falach Moshe Aftalion Eyal Epstein David Gur Theodor Chitlaru Einat B. Vitner Sharon Melamed Boaz Politi Ayelet Zauberman Shirley Lazar Adi Beth-Din Yentl Evgy Shmuel Yitzhaki Shmuel C. Shapira Tomer Israely Ohad Mazor
author_facet	Ronit Rosenfeld Tal Noy-Porat Adva Mechaly Efi Makdasi Yinon Levy Ron Alcalay Reut Falach Moshe Aftalion Eyal Epstein David Gur Theodor Chitlaru Einat B. Vitner Sharon Melamed Boaz Politi Ayelet Zauberman Shirley Lazar Adi Beth-Din Yentl Evgy Shmuel Yitzhaki Shmuel C. Shapira Tomer Israely Ohad Mazor
author_sort	Ronit Rosenfeld
title	Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
title_short	Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
title_full	Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
title_fullStr	Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
title_full_unstemmed	Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
title_sort	post-exposure protection of sars-cov-2 lethal infected k18-hace2 transgenic mice by neutralizing human monoclonal antibody
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/46809b3d714542f1b041f07ea3d49be0
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Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody

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