Peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees

Abstract We present a novel way to select for highly polygenic traits. For millennia, humans have used observable phenotypes to selectively breed stronger or more productive livestock and crops. Selection on genotype, using single-nucleotide polymorphisms (SNPs) and genome profiling, is also now app...

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Autores principales:	M. Marta Guarna, Shelley E. Hoover, Elizabeth Huxter, Heather Higo, Kyung-Mee Moon, Dominik Domanski, Miriam E. F. Bixby, Andony P. Melathopoulos, Abdullah Ibrahim, Michael Peirson, Suresh Desai, Derek Micholson, Rick White, Christoph H. Borchers, Robert W. Currie, Stephen F. Pernal, Leonard J. Foster
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4683084c354f4d458a3a67df2b978508
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spelling	oai:doaj.org-article:4683084c354f4d458a3a67df2b9785082021-12-02T16:07:04ZPeptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees10.1038/s41598-017-08464-22045-2322https://doaj.org/article/4683084c354f4d458a3a67df2b9785082017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08464-2https://doaj.org/toc/2045-2322Abstract We present a novel way to select for highly polygenic traits. For millennia, humans have used observable phenotypes to selectively breed stronger or more productive livestock and crops. Selection on genotype, using single-nucleotide polymorphisms (SNPs) and genome profiling, is also now applied broadly in livestock breeding programs; however, selection on protein/peptide or mRNA expression markers has not yet been proven useful. Here we demonstrate the utility of protein markers to select for disease-resistant hygienic behavior in the European honey bee (Apis mellifera L.). Robust, mechanistically-linked protein expression markers, by integrating cis- and trans- effects from many genomic loci, may overcome limitations of genomic markers to allow for selection. After three generations of selection, the resulting marker-selected stock outperformed an unselected benchmark stock in terms of hygienic behavior, and had improved survival when challenged with a bacterial disease or a parasitic mite, similar to bees selected using a phenotype–based assessment for this trait. This is the first demonstration of the efficacy of protein markers for industrial selective breeding in any agricultural species, plant or animal.M. Marta GuarnaShelley E. HooverElizabeth HuxterHeather HigoKyung-Mee MoonDominik DomanskiMiriam E. F. BixbyAndony P. MelathopoulosAbdullah IbrahimMichael PeirsonSuresh DesaiDerek MicholsonRick WhiteChristoph H. BorchersRobert W. CurrieStephen F. PernalLeonard J. FosterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Marta Guarna Shelley E. Hoover Elizabeth Huxter Heather Higo Kyung-Mee Moon Dominik Domanski Miriam E. F. Bixby Andony P. Melathopoulos Abdullah Ibrahim Michael Peirson Suresh Desai Derek Micholson Rick White Christoph H. Borchers Robert W. Currie Stephen F. Pernal Leonard J. Foster Peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees
description	Abstract We present a novel way to select for highly polygenic traits. For millennia, humans have used observable phenotypes to selectively breed stronger or more productive livestock and crops. Selection on genotype, using single-nucleotide polymorphisms (SNPs) and genome profiling, is also now applied broadly in livestock breeding programs; however, selection on protein/peptide or mRNA expression markers has not yet been proven useful. Here we demonstrate the utility of protein markers to select for disease-resistant hygienic behavior in the European honey bee (Apis mellifera L.). Robust, mechanistically-linked protein expression markers, by integrating cis- and trans- effects from many genomic loci, may overcome limitations of genomic markers to allow for selection. After three generations of selection, the resulting marker-selected stock outperformed an unselected benchmark stock in terms of hygienic behavior, and had improved survival when challenged with a bacterial disease or a parasitic mite, similar to bees selected using a phenotype–based assessment for this trait. This is the first demonstration of the efficacy of protein markers for industrial selective breeding in any agricultural species, plant or animal.
format	article
author	M. Marta Guarna Shelley E. Hoover Elizabeth Huxter Heather Higo Kyung-Mee Moon Dominik Domanski Miriam E. F. Bixby Andony P. Melathopoulos Abdullah Ibrahim Michael Peirson Suresh Desai Derek Micholson Rick White Christoph H. Borchers Robert W. Currie Stephen F. Pernal Leonard J. Foster
author_facet	M. Marta Guarna Shelley E. Hoover Elizabeth Huxter Heather Higo Kyung-Mee Moon Dominik Domanski Miriam E. F. Bixby Andony P. Melathopoulos Abdullah Ibrahim Michael Peirson Suresh Desai Derek Micholson Rick White Christoph H. Borchers Robert W. Currie Stephen F. Pernal Leonard J. Foster
author_sort	M. Marta Guarna
title	Peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees
title_short	Peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees
title_full	Peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees
title_fullStr	Peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees
title_full_unstemmed	Peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees
title_sort	peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4683084c354f4d458a3a67df2b978508
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Peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees

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