INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN

Abstract. We have performed a study of 117 children (106 with BА, and 11, a comparison group). Upon examination of BA patients, they exhibited high rates of pneumotropic intracellular infections more frequent is found out, in comparison with healthy children, endocellular infection pathogens, in par...

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Autores principales:	Е. N. Suprun, V. K. Kozlov, O. I. Morozova, M. V. Efimenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	bronchial asthma cytomegalovirus immunity children Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/468906ac55114f458e78d4c7a8e00c60
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spelling	oai:doaj.org-article:468906ac55114f458e78d4c7a8e00c602021-11-18T08:03:40ZINFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN1563-06252313-741X10.15789/1563-0625-2012-3-201-206https://doaj.org/article/468906ac55114f458e78d4c7a8e00c602014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/347https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We have performed a study of 117 children (106 with BА, and 11, a comparison group). Upon examination of BA patients, they exhibited high rates of pneumotropic intracellular infections more frequent is found out, in comparison with healthy children, endocellular infection pathogens, in particular, cytomegalovirus (CMV), as shown by more frequent detection of specific IgM, IgG, and detection of virus-specific DNA in sputum samples of the sick children suffering with BA. In the children with BА shedding CMV DNA with sputum, a more severe clinical course of the disease was shown, as evidenced by more frequent bronchial obstruction episodes, and more severe symptoms. Decreased levels of all lymphocyte subpopulations was revealed in the patients, but in CMV-positive children, this drop was more pronounced, and accompanied by increase in CD4+ and decrease in CD8+ subpopulations, higher levels of IgA, IgM, and IgG, as well as stronger phagocytic activity. Exacerbation of BA significantly correlates with CD8+ numbers, along with correlations between presence of anti-CMV IgG and amounts of CD16+, CD16a+ cells.Е. N. SuprunV. K. KozlovO. I. MorozovaM. V. EfimenkoSPb RAACIarticlebronchial asthmacytomegalovirusimmunitychildrenImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 3, Pp 201-206 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	bronchial asthma cytomegalovirus immunity children Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma cytomegalovirus immunity children Immunologic diseases. Allergy RC581-607 Е. N. Suprun V. K. Kozlov O. I. Morozova M. V. Efimenko INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN
description	Abstract. We have performed a study of 117 children (106 with BА, and 11, a comparison group). Upon examination of BA patients, they exhibited high rates of pneumotropic intracellular infections more frequent is found out, in comparison with healthy children, endocellular infection pathogens, in particular, cytomegalovirus (CMV), as shown by more frequent detection of specific IgM, IgG, and detection of virus-specific DNA in sputum samples of the sick children suffering with BA. In the children with BА shedding CMV DNA with sputum, a more severe clinical course of the disease was shown, as evidenced by more frequent bronchial obstruction episodes, and more severe symptoms. Decreased levels of all lymphocyte subpopulations was revealed in the patients, but in CMV-positive children, this drop was more pronounced, and accompanied by increase in CD4+ and decrease in CD8+ subpopulations, higher levels of IgA, IgM, and IgG, as well as stronger phagocytic activity. Exacerbation of BA significantly correlates with CD8+ numbers, along with correlations between presence of anti-CMV IgG and amounts of CD16+, CD16a+ cells.
format	article
author	Е. N. Suprun V. K. Kozlov O. I. Morozova M. V. Efimenko
author_facet	Е. N. Suprun V. K. Kozlov O. I. Morozova M. V. Efimenko
author_sort	Е. N. Suprun
title	INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN
title_short	INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN
title_full	INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN
title_fullStr	INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN
title_full_unstemmed	INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN
title_sort	influence of cytomegalovirus persistence upon clinical course of bronchial asthma (ba) in children
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/468906ac55114f458e78d4c7a8e00c60
work_keys_str_mv	AT ensuprun influenceofcytomegaloviruspersistenceuponclinicalcourseofbronchialasthmabainchildren AT vkkozlov influenceofcytomegaloviruspersistenceuponclinicalcourseofbronchialasthmabainchildren AT oimorozova influenceofcytomegaloviruspersistenceuponclinicalcourseofbronchialasthmabainchildren AT mvefimenko influenceofcytomegaloviruspersistenceuponclinicalcourseofbronchialasthmabainchildren
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INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN

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