EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION

Abstract. Intraperitoneal injection of rIL-1β (1 mkg/kg once a day within 5 days) during proceeding fractional irradiations (0,5 Gy once in day, the beginning of therapy after the total doze 20 Gy) prevents the further decrease in quantity of leukocytes in peripheral blood and oppression of alkaline...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. N. Grebenyuk, V. V. Konev, A. A. Timoshevskiy
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	fractional irradiations ril-1β leukocytes neutrophils lymphocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/468dea7115904771ae8eead46bd43e79
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:468dea7115904771ae8eead46bd43e79
record_format	dspace
spelling	oai:doaj.org-article:468dea7115904771ae8eead46bd43e792021-11-18T08:03:43ZEXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION1563-06252313-741X10.15789/1563-0625-2005-5-6-605-610https://doaj.org/article/468dea7115904771ae8eead46bd43e792014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/652https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Intraperitoneal injection of rIL-1β (1 mkg/kg once a day within 5 days) during proceeding fractional irradiations (0,5 Gy once in day, the beginning of therapy after the total doze 20 Gy) prevents the further decrease in quantity of leukocytes in peripheral blood and oppression of alkaline phosphatase activity in neutrophils of irradiated rats, and also accelerates their restoration after cessation of radiatijn exposure. Restoration of the general number of leukocytes, absolute quantity of neutrophils and lymphocytes, normalization of the alkaline phosphatase activity in neutrophils of rats after the end of fractional irradiations in a total doze 25 Gy at course administration of rIL-1β occur in earlier terms, than in the animals of the control group.A. N. GrebenyukV. V. KonevA. A. TimoshevskiySPb RAACIarticlefractional irradiationsril-1βleukocytesneutrophilslymphocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 5-6, Pp 605-610 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	fractional irradiations ril-1β leukocytes neutrophils lymphocytes Immunologic diseases. Allergy RC581-607
spellingShingle	fractional irradiations ril-1β leukocytes neutrophils lymphocytes Immunologic diseases. Allergy RC581-607 A. N. Grebenyuk V. V. Konev A. A. Timoshevskiy EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
description	Abstract. Intraperitoneal injection of rIL-1β (1 mkg/kg once a day within 5 days) during proceeding fractional irradiations (0,5 Gy once in day, the beginning of therapy after the total doze 20 Gy) prevents the further decrease in quantity of leukocytes in peripheral blood and oppression of alkaline phosphatase activity in neutrophils of irradiated rats, and also accelerates their restoration after cessation of radiatijn exposure. Restoration of the general number of leukocytes, absolute quantity of neutrophils and lymphocytes, normalization of the alkaline phosphatase activity in neutrophils of rats after the end of fractional irradiations in a total doze 25 Gy at course administration of rIL-1β occur in earlier terms, than in the animals of the control group.
format	article
author	A. N. Grebenyuk V. V. Konev A. A. Timoshevskiy
author_facet	A. N. Grebenyuk V. V. Konev A. A. Timoshevskiy
author_sort	A. N. Grebenyuk
title	EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
title_short	EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
title_full	EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
title_fullStr	EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
title_full_unstemmed	EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
title_sort	experimental proof of the efficacy of recombinant il-1β in fractional irradiation
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/468dea7115904771ae8eead46bd43e79
work_keys_str_mv	AT angrebenyuk experimentalproofoftheefficacyofrecombinantil1binfractionalirradiation AT vvkonev experimentalproofoftheefficacyofrecombinantil1binfractionalirradiation AT aatimoshevskiy experimentalproofoftheefficacyofrecombinantil1binfractionalirradiation
_version_	1718422413213958144

EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION

Ejemplares similares