Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

The contribution of ligands for cytokine receptor dimerization is still not fully understood. Here, the authors show the efficient ligand-induced dimerization of type II interleukin-4 receptor at the plasma membrane and the kinetic trapping of signalling complexes by actin-dependent membrane microdo...

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Autores principales:	David Richter, Ignacio Moraga, Hauke Winkelmann, Oliver Birkholz, Stephan Wilmes, Markos Schulte, Michael Kraich, Hella Kenneweg, Oliver Beutel, Philipp Selenschik, Dirk Paterok, Martynas Gavutis, Thomas Schmidt, K. Christopher Garcia, Thomas D. Müller, Jacob Piehler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/468ea883eae44e69b79d347c613a8344
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spelling	oai:doaj.org-article:468ea883eae44e69b79d347c613a83442021-12-02T14:42:45ZLigand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments10.1038/ncomms159762041-1723https://doaj.org/article/468ea883eae44e69b79d347c613a83442017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15976https://doaj.org/toc/2041-1723The contribution of ligands for cytokine receptor dimerization is still not fully understood. Here, the authors show the efficient ligand-induced dimerization of type II interleukin-4 receptor at the plasma membrane and the kinetic trapping of signalling complexes by actin-dependent membrane microdomains.David RichterIgnacio MoragaHauke WinkelmannOliver BirkholzStephan WilmesMarkos SchulteMichael KraichHella KennewegOliver BeutelPhilipp SelenschikDirk PaterokMartynas GavutisThomas SchmidtK. Christopher GarciaThomas D. MüllerJacob PiehlerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Richter Ignacio Moraga Hauke Winkelmann Oliver Birkholz Stephan Wilmes Markos Schulte Michael Kraich Hella Kenneweg Oliver Beutel Philipp Selenschik Dirk Paterok Martynas Gavutis Thomas Schmidt K. Christopher Garcia Thomas D. Müller Jacob Piehler Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments
description	The contribution of ligands for cytokine receptor dimerization is still not fully understood. Here, the authors show the efficient ligand-induced dimerization of type II interleukin-4 receptor at the plasma membrane and the kinetic trapping of signalling complexes by actin-dependent membrane microdomains.
format	article
author	David Richter Ignacio Moraga Hauke Winkelmann Oliver Birkholz Stephan Wilmes Markos Schulte Michael Kraich Hella Kenneweg Oliver Beutel Philipp Selenschik Dirk Paterok Martynas Gavutis Thomas Schmidt K. Christopher Garcia Thomas D. Müller Jacob Piehler
author_facet	David Richter Ignacio Moraga Hauke Winkelmann Oliver Birkholz Stephan Wilmes Markos Schulte Michael Kraich Hella Kenneweg Oliver Beutel Philipp Selenschik Dirk Paterok Martynas Gavutis Thomas Schmidt K. Christopher Garcia Thomas D. Müller Jacob Piehler
author_sort	David Richter
title	Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments
title_short	Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments
title_full	Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments
title_fullStr	Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments
title_full_unstemmed	Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments
title_sort	ligand-induced type ii interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/468ea883eae44e69b79d347c613a8344
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Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

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