Enhanced lysosomal degradation maintains the quiescent state of neural stem cells

It remains unclear why quiescent neural stem cells (qNSCs) in the subventricular zone of the mouse brain have enlarged lysosomes. Here, authors demonstrate that qNSCs exhibit higher lysosomal activity and degrade activated EGF receptor by endolysosomal degradation more rapidly than proliferating NSC...

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Autores principales:	Taeko Kobayashi, Wenhui Piao, Toshiya Takamura, Hiroshi Kori, Hitoshi Miyachi, Satsuki Kitano, Yumiko Iwamoto, Mayumi Yamada, Itaru Imayoshi, Seiji Shioda, Andrea Ballabio, Ryoichiro Kageyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4691a3fa38a34ed4b3aef31a73471536
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spelling	oai:doaj.org-article:4691a3fa38a34ed4b3aef31a734715362021-12-02T14:39:01ZEnhanced lysosomal degradation maintains the quiescent state of neural stem cells10.1038/s41467-019-13203-42041-1723https://doaj.org/article/4691a3fa38a34ed4b3aef31a734715362019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13203-4https://doaj.org/toc/2041-1723It remains unclear why quiescent neural stem cells (qNSCs) in the subventricular zone of the mouse brain have enlarged lysosomes. Here, authors demonstrate that qNSCs exhibit higher lysosomal activity and degrade activated EGF receptor by endolysosomal degradation more rapidly than proliferating NSCs, which prevents the NSC exit from quiescence.Taeko KobayashiWenhui PiaoToshiya TakamuraHiroshi KoriHitoshi MiyachiSatsuki KitanoYumiko IwamotoMayumi YamadaItaru ImayoshiSeiji ShiodaAndrea BallabioRyoichiro KageyamaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Taeko Kobayashi Wenhui Piao Toshiya Takamura Hiroshi Kori Hitoshi Miyachi Satsuki Kitano Yumiko Iwamoto Mayumi Yamada Itaru Imayoshi Seiji Shioda Andrea Ballabio Ryoichiro Kageyama Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
description	It remains unclear why quiescent neural stem cells (qNSCs) in the subventricular zone of the mouse brain have enlarged lysosomes. Here, authors demonstrate that qNSCs exhibit higher lysosomal activity and degrade activated EGF receptor by endolysosomal degradation more rapidly than proliferating NSCs, which prevents the NSC exit from quiescence.
format	article
author	Taeko Kobayashi Wenhui Piao Toshiya Takamura Hiroshi Kori Hitoshi Miyachi Satsuki Kitano Yumiko Iwamoto Mayumi Yamada Itaru Imayoshi Seiji Shioda Andrea Ballabio Ryoichiro Kageyama
author_facet	Taeko Kobayashi Wenhui Piao Toshiya Takamura Hiroshi Kori Hitoshi Miyachi Satsuki Kitano Yumiko Iwamoto Mayumi Yamada Itaru Imayoshi Seiji Shioda Andrea Ballabio Ryoichiro Kageyama
author_sort	Taeko Kobayashi
title	Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
title_short	Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
title_full	Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
title_fullStr	Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
title_full_unstemmed	Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
title_sort	enhanced lysosomal degradation maintains the quiescent state of neural stem cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4691a3fa38a34ed4b3aef31a73471536
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Enhanced lysosomal degradation maintains the quiescent state of neural stem cells

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