The clinical impact of cerebellar grey matter pathology in multiple sclerosis.

<h4>Background</h4>The cerebellum is an important site for cortical demyelination in multiple sclerosis, but the functional significance of this finding is not fully understood.<h4>Objective</h4>To evaluate the clinical and cognitive impact of cerebellar grey-matter pathology...

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Autores principales:	Alfredo Damasceno, Benito Pereira Damasceno, Fernando Cendes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/469283f4d2b743c5be590ac41ee04693
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spelling	oai:doaj.org-article:469283f4d2b743c5be590ac41ee046932021-11-18T08:21:06ZThe clinical impact of cerebellar grey matter pathology in multiple sclerosis.1932-620310.1371/journal.pone.0096193https://doaj.org/article/469283f4d2b743c5be590ac41ee046932014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24789257/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The cerebellum is an important site for cortical demyelination in multiple sclerosis, but the functional significance of this finding is not fully understood.<h4>Objective</h4>To evaluate the clinical and cognitive impact of cerebellar grey-matter pathology in multiple sclerosis patients.<h4>Methods</h4>Forty-two relapsing-remitting multiple sclerosis patients and 30 controls underwent clinical assessment including the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale (EDSS) and cerebellar functional system (FS) score, and cognitive evaluation, including the Paced Auditory Serial Addition Test (PASAT) and the Symbol-Digit Modalities Test (SDMT). Magnetic resonance imaging was performed with a 3T scanner and variables of interest were: brain white-matter and cortical lesion load, cerebellar intracortical and leukocortical lesion volumes, and brain cortical and cerebellar white-matter and grey-matter volumes.<h4>Results</h4>After multivariate analysis high burden of cerebellar intracortical lesions was the only predictor for the EDSS (p<0.001), cerebellar FS (p = 0.002), arm function (p = 0.049), and for leg function (p<0.001). Patients with high burden of cerebellar leukocortical lesions had lower PASAT scores (p = 0.013), while patients with greater volumes of cerebellar intracortical lesions had worse SDMT scores (p = 0.015).<h4>Conclusions</h4>Cerebellar grey-matter pathology is widely present and contributes to clinical dysfunction in relapsing-remitting multiple sclerosis patients, independently of brain grey-matter damage.Alfredo DamascenoBenito Pereira DamascenoFernando CendesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96193 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alfredo Damasceno Benito Pereira Damasceno Fernando Cendes The clinical impact of cerebellar grey matter pathology in multiple sclerosis.
description	<h4>Background</h4>The cerebellum is an important site for cortical demyelination in multiple sclerosis, but the functional significance of this finding is not fully understood.<h4>Objective</h4>To evaluate the clinical and cognitive impact of cerebellar grey-matter pathology in multiple sclerosis patients.<h4>Methods</h4>Forty-two relapsing-remitting multiple sclerosis patients and 30 controls underwent clinical assessment including the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale (EDSS) and cerebellar functional system (FS) score, and cognitive evaluation, including the Paced Auditory Serial Addition Test (PASAT) and the Symbol-Digit Modalities Test (SDMT). Magnetic resonance imaging was performed with a 3T scanner and variables of interest were: brain white-matter and cortical lesion load, cerebellar intracortical and leukocortical lesion volumes, and brain cortical and cerebellar white-matter and grey-matter volumes.<h4>Results</h4>After multivariate analysis high burden of cerebellar intracortical lesions was the only predictor for the EDSS (p<0.001), cerebellar FS (p = 0.002), arm function (p = 0.049), and for leg function (p<0.001). Patients with high burden of cerebellar leukocortical lesions had lower PASAT scores (p = 0.013), while patients with greater volumes of cerebellar intracortical lesions had worse SDMT scores (p = 0.015).<h4>Conclusions</h4>Cerebellar grey-matter pathology is widely present and contributes to clinical dysfunction in relapsing-remitting multiple sclerosis patients, independently of brain grey-matter damage.
format	article
author	Alfredo Damasceno Benito Pereira Damasceno Fernando Cendes
author_facet	Alfredo Damasceno Benito Pereira Damasceno Fernando Cendes
author_sort	Alfredo Damasceno
title	The clinical impact of cerebellar grey matter pathology in multiple sclerosis.
title_short	The clinical impact of cerebellar grey matter pathology in multiple sclerosis.
title_full	The clinical impact of cerebellar grey matter pathology in multiple sclerosis.
title_fullStr	The clinical impact of cerebellar grey matter pathology in multiple sclerosis.
title_full_unstemmed	The clinical impact of cerebellar grey matter pathology in multiple sclerosis.
title_sort	clinical impact of cerebellar grey matter pathology in multiple sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/469283f4d2b743c5be590ac41ee04693
work_keys_str_mv	AT alfredodamasceno theclinicalimpactofcerebellargreymatterpathologyinmultiplesclerosis AT benitopereiradamasceno theclinicalimpactofcerebellargreymatterpathologyinmultiplesclerosis AT fernandocendes theclinicalimpactofcerebellargreymatterpathologyinmultiplesclerosis AT alfredodamasceno clinicalimpactofcerebellargreymatterpathologyinmultiplesclerosis AT benitopereiradamasceno clinicalimpactofcerebellargreymatterpathologyinmultiplesclerosis AT fernandocendes clinicalimpactofcerebellargreymatterpathologyinmultiplesclerosis
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The clinical impact of cerebellar grey matter pathology in multiple sclerosis.

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