Modeling the impact of drug interactions on therapeutic selectivity

While drugs can interact in both target and off-target cell types, more favorable interaction in the target cell may nevertheless allow for a therapeutic window. Here, the authors show, using two yeast species as a model, that differential drug interactions indeed adjust the selective window.

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Autores principales:	Zohar B. Weinstein, Nurdan Kuru, Szilvia Kiriakov, Adam C. Palmer, Ahmad S. Khalil, Paul A. Clemons, Muhammad H. Zaman, Frederick P. Roth, Murat Cokol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/469370dc8ba0481e8780ba4f7a1c399a
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spelling	oai:doaj.org-article:469370dc8ba0481e8780ba4f7a1c399a2021-12-02T16:50:08ZModeling the impact of drug interactions on therapeutic selectivity10.1038/s41467-018-05954-32041-1723https://doaj.org/article/469370dc8ba0481e8780ba4f7a1c399a2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05954-3https://doaj.org/toc/2041-1723While drugs can interact in both target and off-target cell types, more favorable interaction in the target cell may nevertheless allow for a therapeutic window. Here, the authors show, using two yeast species as a model, that differential drug interactions indeed adjust the selective window.Zohar B. WeinsteinNurdan KuruSzilvia KiriakovAdam C. PalmerAhmad S. KhalilPaul A. ClemonsMuhammad H. ZamanFrederick P. RothMurat CokolNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zohar B. Weinstein Nurdan Kuru Szilvia Kiriakov Adam C. Palmer Ahmad S. Khalil Paul A. Clemons Muhammad H. Zaman Frederick P. Roth Murat Cokol Modeling the impact of drug interactions on therapeutic selectivity
description	While drugs can interact in both target and off-target cell types, more favorable interaction in the target cell may nevertheless allow for a therapeutic window. Here, the authors show, using two yeast species as a model, that differential drug interactions indeed adjust the selective window.
format	article
author	Zohar B. Weinstein Nurdan Kuru Szilvia Kiriakov Adam C. Palmer Ahmad S. Khalil Paul A. Clemons Muhammad H. Zaman Frederick P. Roth Murat Cokol
author_facet	Zohar B. Weinstein Nurdan Kuru Szilvia Kiriakov Adam C. Palmer Ahmad S. Khalil Paul A. Clemons Muhammad H. Zaman Frederick P. Roth Murat Cokol
author_sort	Zohar B. Weinstein
title	Modeling the impact of drug interactions on therapeutic selectivity
title_short	Modeling the impact of drug interactions on therapeutic selectivity
title_full	Modeling the impact of drug interactions on therapeutic selectivity
title_fullStr	Modeling the impact of drug interactions on therapeutic selectivity
title_full_unstemmed	Modeling the impact of drug interactions on therapeutic selectivity
title_sort	modeling the impact of drug interactions on therapeutic selectivity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/469370dc8ba0481e8780ba4f7a1c399a
work_keys_str_mv	AT zoharbweinstein modelingtheimpactofdruginteractionsontherapeuticselectivity AT nurdankuru modelingtheimpactofdruginteractionsontherapeuticselectivity AT szilviakiriakov modelingtheimpactofdruginteractionsontherapeuticselectivity AT adamcpalmer modelingtheimpactofdruginteractionsontherapeuticselectivity AT ahmadskhalil modelingtheimpactofdruginteractionsontherapeuticselectivity AT paulaclemons modelingtheimpactofdruginteractionsontherapeuticselectivity AT muhammadhzaman modelingtheimpactofdruginteractionsontherapeuticselectivity AT frederickproth modelingtheimpactofdruginteractionsontherapeuticselectivity AT muratcokol modelingtheimpactofdruginteractionsontherapeuticselectivity
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Modeling the impact of drug interactions on therapeutic selectivity

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