Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research

Abstract The All of Us Research Program was designed to enable broad-based precision medicine research in a cohort of unprecedented scale and diversity. Hypertension (HTN) is a major public health concern. The validity of HTN data and definition of hypertension cases in the All of Us (AoU) Research...

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Autores principales:	Paulette D. Chandler, Cheryl R. Clark, Guohai Zhou, Nyia L. Noel, Confidence Achilike, Lizette Mendez, Andrea H. Ramirez, Roxana Loperena-Cortes, Kelsey Mayo, Elizabeth Cohn, Lucila Ohno-Machado, Eric Boerwinkle, Mine Cicek, Jun Qian, Sheri Schully, Francis Ratsimbazafy, Stephen Mockrin, Kelly Gebo, Julien J. Dedier, Shawn N. Murphy, Jordan W. Smoller, Elizabeth W. Karlson, the All of Us Research Program Investigators
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/46937ed79fb4451397e12dd210cbf27a
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spelling	oai:doaj.org-article:46937ed79fb4451397e12dd210cbf27a2021-12-02T17:45:02ZHypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research10.1038/s41598-021-92143-w2045-2322https://doaj.org/article/46937ed79fb4451397e12dd210cbf27a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92143-whttps://doaj.org/toc/2045-2322Abstract The All of Us Research Program was designed to enable broad-based precision medicine research in a cohort of unprecedented scale and diversity. Hypertension (HTN) is a major public health concern. The validity of HTN data and definition of hypertension cases in the All of Us (AoU) Research Program for use in rule-based algorithms is unknown. In this cross-sectional, population-based study, we compare HTN prevalence in the AoU Research Program to HTN prevalence in the 2015–2016 National Health and Nutrition Examination Survey (NHANES). We used AoU baseline data from patient (age ≥ 18) measurements (PM), surveys, and electronic health record (EHR) blood pressure measurements. We retrospectively examined the prevalence of HTN in the EHR cohort using Systemized Nomenclature of Medicine (SNOMED) codes and blood pressure medications recorded in the EHR. We defined HTN as the participant having at least 2 HTN diagnosis/billing codes on separate dates in the EHR data AND at least one HTN medication. We calculated an age-standardized HTN prevalence according to the age distribution of the U.S. Census, using 3 groups (18–39, 40–59, and ≥ 60). Among the 185,770 participants enrolled in the AoU Cohort (mean age at enrollment = 51.2 years) available in a Researcher Workbench as of October 2019, EHR data was available for at least one SNOMED code from 112,805 participants, medications for 104,230 participants, and 103,490 participants had both medication and SNOMED data. The total number of persons with SNOMED codes on at least two distinct dates and at least one antihypertensive medication was 33,310 for a crude prevalence of HTN of 32.2%. AoU age-adjusted HTN prevalence was 27.9% using 3 groups compared to 29.6% in NHANES. The AoU cohort is a growing source of diverse longitudinal data to study hypertension nationwide and develop precision rule-based algorithms for use in hypertension treatment and prevention research. The prevalence of hypertension in this cohort is similar to that in prior population-based surveys.Paulette D. ChandlerCheryl R. ClarkGuohai ZhouNyia L. NoelConfidence AchilikeLizette MendezAndrea H. RamirezRoxana Loperena-CortesKelsey MayoElizabeth CohnLucila Ohno-MachadoEric BoerwinkleMine CicekJun QianSheri SchullyFrancis RatsimbazafyStephen MockrinKelly GeboJulien J. DedierShawn N. MurphyJordan W. SmollerElizabeth W. Karlsonthe All of Us Research Program InvestigatorsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paulette D. Chandler Cheryl R. Clark Guohai Zhou Nyia L. Noel Confidence Achilike Lizette Mendez Andrea H. Ramirez Roxana Loperena-Cortes Kelsey Mayo Elizabeth Cohn Lucila Ohno-Machado Eric Boerwinkle Mine Cicek Jun Qian Sheri Schully Francis Ratsimbazafy Stephen Mockrin Kelly Gebo Julien J. Dedier Shawn N. Murphy Jordan W. Smoller Elizabeth W. Karlson the All of Us Research Program Investigators Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research
description	Abstract The All of Us Research Program was designed to enable broad-based precision medicine research in a cohort of unprecedented scale and diversity. Hypertension (HTN) is a major public health concern. The validity of HTN data and definition of hypertension cases in the All of Us (AoU) Research Program for use in rule-based algorithms is unknown. In this cross-sectional, population-based study, we compare HTN prevalence in the AoU Research Program to HTN prevalence in the 2015–2016 National Health and Nutrition Examination Survey (NHANES). We used AoU baseline data from patient (age ≥ 18) measurements (PM), surveys, and electronic health record (EHR) blood pressure measurements. We retrospectively examined the prevalence of HTN in the EHR cohort using Systemized Nomenclature of Medicine (SNOMED) codes and blood pressure medications recorded in the EHR. We defined HTN as the participant having at least 2 HTN diagnosis/billing codes on separate dates in the EHR data AND at least one HTN medication. We calculated an age-standardized HTN prevalence according to the age distribution of the U.S. Census, using 3 groups (18–39, 40–59, and ≥ 60). Among the 185,770 participants enrolled in the AoU Cohort (mean age at enrollment = 51.2 years) available in a Researcher Workbench as of October 2019, EHR data was available for at least one SNOMED code from 112,805 participants, medications for 104,230 participants, and 103,490 participants had both medication and SNOMED data. The total number of persons with SNOMED codes on at least two distinct dates and at least one antihypertensive medication was 33,310 for a crude prevalence of HTN of 32.2%. AoU age-adjusted HTN prevalence was 27.9% using 3 groups compared to 29.6% in NHANES. The AoU cohort is a growing source of diverse longitudinal data to study hypertension nationwide and develop precision rule-based algorithms for use in hypertension treatment and prevention research. The prevalence of hypertension in this cohort is similar to that in prior population-based surveys.
format	article
author	Paulette D. Chandler Cheryl R. Clark Guohai Zhou Nyia L. Noel Confidence Achilike Lizette Mendez Andrea H. Ramirez Roxana Loperena-Cortes Kelsey Mayo Elizabeth Cohn Lucila Ohno-Machado Eric Boerwinkle Mine Cicek Jun Qian Sheri Schully Francis Ratsimbazafy Stephen Mockrin Kelly Gebo Julien J. Dedier Shawn N. Murphy Jordan W. Smoller Elizabeth W. Karlson the All of Us Research Program Investigators
author_facet	Paulette D. Chandler Cheryl R. Clark Guohai Zhou Nyia L. Noel Confidence Achilike Lizette Mendez Andrea H. Ramirez Roxana Loperena-Cortes Kelsey Mayo Elizabeth Cohn Lucila Ohno-Machado Eric Boerwinkle Mine Cicek Jun Qian Sheri Schully Francis Ratsimbazafy Stephen Mockrin Kelly Gebo Julien J. Dedier Shawn N. Murphy Jordan W. Smoller Elizabeth W. Karlson the All of Us Research Program Investigators
author_sort	Paulette D. Chandler
title	Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research
title_short	Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research
title_full	Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research
title_fullStr	Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research
title_full_unstemmed	Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research
title_sort	hypertension prevalence in the all of us research program among groups traditionally underrepresented in medical research
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/46937ed79fb4451397e12dd210cbf27a
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Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research

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