Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer

Cancers accumulate multiple single copy number alterations, but their impact is unclear. Here, the authors computationally demonstrate a disruption of genes associated with autophagy in ovarian cancer, show impact on autophagic flux, and note the efficacy of autophagy drugs in preclinical models.

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Autores principales:	Joe Ryan Delaney, Chandni B. Patel, Katelyn McCabe Willis, Mina Haghighiabyaneh, Joshua Axelrod, Isabelle Tancioni, Dan Lu, Jaidev Bapat, Shanique Young, Octavia Cadassou, Alena Bartakova, Parthiv Sheth, Carley Haft, Sandra Hui, Cheryl Saenz, David D. Schlaepfer, Olivier Harismendy, Dwayne G. Stupack
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4693ab4669b34978ad4a226632a7b4a7
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spelling	oai:doaj.org-article:4693ab4669b34978ad4a226632a7b4a72021-12-02T15:39:00ZHaploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer10.1038/ncomms144232041-1723https://doaj.org/article/4693ab4669b34978ad4a226632a7b4a72017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14423https://doaj.org/toc/2041-1723Cancers accumulate multiple single copy number alterations, but their impact is unclear. Here, the authors computationally demonstrate a disruption of genes associated with autophagy in ovarian cancer, show impact on autophagic flux, and note the efficacy of autophagy drugs in preclinical models.Joe Ryan DelaneyChandni B. PatelKatelyn McCabe WillisMina HaghighiabyanehJoshua AxelrodIsabelle TancioniDan LuJaidev BapatShanique YoungOctavia CadassouAlena BartakovaParthiv ShethCarley HaftSandra HuiCheryl SaenzDavid D. SchlaepferOlivier HarismendyDwayne G. StupackNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joe Ryan Delaney Chandni B. Patel Katelyn McCabe Willis Mina Haghighiabyaneh Joshua Axelrod Isabelle Tancioni Dan Lu Jaidev Bapat Shanique Young Octavia Cadassou Alena Bartakova Parthiv Sheth Carley Haft Sandra Hui Cheryl Saenz David D. Schlaepfer Olivier Harismendy Dwayne G. Stupack Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer
description	Cancers accumulate multiple single copy number alterations, but their impact is unclear. Here, the authors computationally demonstrate a disruption of genes associated with autophagy in ovarian cancer, show impact on autophagic flux, and note the efficacy of autophagy drugs in preclinical models.
format	article
author	Joe Ryan Delaney Chandni B. Patel Katelyn McCabe Willis Mina Haghighiabyaneh Joshua Axelrod Isabelle Tancioni Dan Lu Jaidev Bapat Shanique Young Octavia Cadassou Alena Bartakova Parthiv Sheth Carley Haft Sandra Hui Cheryl Saenz David D. Schlaepfer Olivier Harismendy Dwayne G. Stupack
author_facet	Joe Ryan Delaney Chandni B. Patel Katelyn McCabe Willis Mina Haghighiabyaneh Joshua Axelrod Isabelle Tancioni Dan Lu Jaidev Bapat Shanique Young Octavia Cadassou Alena Bartakova Parthiv Sheth Carley Haft Sandra Hui Cheryl Saenz David D. Schlaepfer Olivier Harismendy Dwayne G. Stupack
author_sort	Joe Ryan Delaney
title	Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer
title_short	Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer
title_full	Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer
title_fullStr	Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer
title_full_unstemmed	Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer
title_sort	haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4693ab4669b34978ad4a226632a7b4a7
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Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer

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