Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats

Drug-induced liver injury (DILI) is the major health problem that resulted from uses of many drugs especially from serious adverse effect of antituberculosis (ATT) drugs. forty eight rats (200-250g) were allocated into six groups (8 rats in each group), and treated as follow: group I: received norma...

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Autores principales:	Abdel-Hameed M.Fayed, Abeer A. A. Salama, Ismaiel E Ismaiel, Taha A. Attia, Elbatran Seham A, Azza Hassan
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2019
Materias:	adiponectin hepatotoxicity isoniazid rats rifampicin solanum nigrum Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2019.63436 https://doaj.org/article/46969e3182144d0b80691eb22737b306
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spelling	oai:doaj.org-article:46969e3182144d0b80691eb22737b3062021-12-02T17:04:13ZProtective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Ratshttps://dx.doi.org/10.21608/javs.2019.634361687-40722090-3308https://doaj.org/article/46969e3182144d0b80691eb22737b3062019-10-01T00:00:00Zhttps://javs.journals.ekb.eg/article_63436.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308Drug-induced liver injury (DILI) is the major health problem that resulted from uses of many drugs especially from serious adverse effect of antituberculosis (ATT) drugs. forty eight rats (200-250g) were allocated into six groups (8 rats in each group), and treated as follow: group I: received normal saline orally; group II: received INH/RFP (50 mg/Kg/day of each) for 28 days orally; group III: received Silymarin (50 mg/kg/day) + INH/RFP for 28 days orally; group IV: received SNME(250 mg/Kg/day) + INH/RFP for 28 days orally; group V: received SNME (500 mg/Kg/day) + INH/RFP for 28 days orally; group VI, received SNME (1000 mg/Kg/day) + INH/RFP for 28 days orally. Co-administration of herbal plant (SNME) with INH/RFP reduced elevated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and (bilirubin total &direct) levels but also decreased the elevated malondialdehyde (MDA) & tumor necrosis factor-α (TNF-α) contents in liver homogenate. Moreover, co-administration of herbal plant (SNME) with INH/RFP increased glutathione peroxidase (GPX) & adiponectin activity. Solanum nigrum administration to rats, in present study, led to a remarkable alteration of histological changes observed in INH/RFP group. It is concluded that Solanum nigrum might be considered as adjuvant drug in treatment of liver disorder and/or as hepatoprotective therapy with anti-tubercular drugs.Abdel-Hameed M.FayedAbeer A. A. SalamaIsmaiel E IsmaielTaha A. AttiaElbatran Seham AAzza HassanEgyptian Society for Animal Managementarticleadiponectinhepatotoxicityisoniazidratsrifampicinsolanum nigrumZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 4, Iss 2, Pp 52-61 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	adiponectin hepatotoxicity isoniazid rats rifampicin solanum nigrum Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	adiponectin hepatotoxicity isoniazid rats rifampicin solanum nigrum Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Abdel-Hameed M.Fayed Abeer A. A. Salama Ismaiel E Ismaiel Taha A. Attia Elbatran Seham A Azza Hassan Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats
description	Drug-induced liver injury (DILI) is the major health problem that resulted from uses of many drugs especially from serious adverse effect of antituberculosis (ATT) drugs. forty eight rats (200-250g) were allocated into six groups (8 rats in each group), and treated as follow: group I: received normal saline orally; group II: received INH/RFP (50 mg/Kg/day of each) for 28 days orally; group III: received Silymarin (50 mg/kg/day) + INH/RFP for 28 days orally; group IV: received SNME(250 mg/Kg/day) + INH/RFP for 28 days orally; group V: received SNME (500 mg/Kg/day) + INH/RFP for 28 days orally; group VI, received SNME (1000 mg/Kg/day) + INH/RFP for 28 days orally. Co-administration of herbal plant (SNME) with INH/RFP reduced elevated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and (bilirubin total &direct) levels but also decreased the elevated malondialdehyde (MDA) & tumor necrosis factor-α (TNF-α) contents in liver homogenate. Moreover, co-administration of herbal plant (SNME) with INH/RFP increased glutathione peroxidase (GPX) & adiponectin activity. Solanum nigrum administration to rats, in present study, led to a remarkable alteration of histological changes observed in INH/RFP group. It is concluded that Solanum nigrum might be considered as adjuvant drug in treatment of liver disorder and/or as hepatoprotective therapy with anti-tubercular drugs.
format	article
author	Abdel-Hameed M.Fayed Abeer A. A. Salama Ismaiel E Ismaiel Taha A. Attia Elbatran Seham A Azza Hassan
author_facet	Abdel-Hameed M.Fayed Abeer A. A. Salama Ismaiel E Ismaiel Taha A. Attia Elbatran Seham A Azza Hassan
author_sort	Abdel-Hameed M.Fayed
title	Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats
title_short	Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats
title_full	Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats
title_fullStr	Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats
title_full_unstemmed	Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats
title_sort	protective effects of solanium nigrum methanolic extract against isoniazid/rifampicin induced hepatotoxicity in rats
publisher	Egyptian Society for Animal Management
publishDate	2019
url	https://dx.doi.org/10.21608/javs.2019.63436 https://doaj.org/article/46969e3182144d0b80691eb22737b306
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Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats

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