Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Here, Reader et al. screen the Medicines for Malaria Venture Pandemic Response Box in parallel against Plasmodiumasexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. They identify two potent transmission-blocking drugs: a histone demethylase inhibitor ML32...

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Autores principales: Janette Reader, Mariëtte E. van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Sabine Ottilie, Anjo Theron, Phanankosi Moyo, Erica Erlank, Luisa Nardini, Nelius Venter, Sonja Lauterbach, Belinda Bezuidenhout, Andre Horatscheck, Ashleigh van Heerden, Natalie J. Spillman, Anne N. Cowell, Jessica Connacher, Daniel Opperman, Lindsey M. Orchard, Manuel Llinás, Eva S. Istvan, Daniel E. Goldberg, Grant A. Boyle, David Calvo, Dalu Mancama, Theresa L. Coetzer, Elizabeth A. Winzeler, James Duffy, Lizette L. Koekemoer, Gregory Basarab, Kelly Chibale, Lyn-Marié Birkholtz
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/469ad5b32c23403795a07ad1d5fdbabe
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spelling oai:doaj.org-article:469ad5b32c23403795a07ad1d5fdbabe2021-12-02T15:22:48ZMultistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box10.1038/s41467-020-20629-82041-1723https://doaj.org/article/469ad5b32c23403795a07ad1d5fdbabe2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20629-8https://doaj.org/toc/2041-1723Here, Reader et al. screen the Medicines for Malaria Venture Pandemic Response Box in parallel against Plasmodiumasexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. They identify two potent transmission-blocking drugs: a histone demethylase inhibitor ML324 and the antitubercular SQ109.Janette ReaderMariëtte E. van der WattDale TaylorClaire Le ManachNimisha MittalSabine OttilieAnjo TheronPhanankosi MoyoErica ErlankLuisa NardiniNelius VenterSonja LauterbachBelinda BezuidenhoutAndre HoratscheckAshleigh van HeerdenNatalie J. SpillmanAnne N. CowellJessica ConnacherDaniel OppermanLindsey M. OrchardManuel LlinásEva S. IstvanDaniel E. GoldbergGrant A. BoyleDavid CalvoDalu MancamaTheresa L. CoetzerElizabeth A. WinzelerJames DuffyLizette L. KoekemoerGregory BasarabKelly ChibaleLyn-Marié BirkholtzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Janette Reader
Mariëtte E. van der Watt
Dale Taylor
Claire Le Manach
Nimisha Mittal
Sabine Ottilie
Anjo Theron
Phanankosi Moyo
Erica Erlank
Luisa Nardini
Nelius Venter
Sonja Lauterbach
Belinda Bezuidenhout
Andre Horatscheck
Ashleigh van Heerden
Natalie J. Spillman
Anne N. Cowell
Jessica Connacher
Daniel Opperman
Lindsey M. Orchard
Manuel Llinás
Eva S. Istvan
Daniel E. Goldberg
Grant A. Boyle
David Calvo
Dalu Mancama
Theresa L. Coetzer
Elizabeth A. Winzeler
James Duffy
Lizette L. Koekemoer
Gregory Basarab
Kelly Chibale
Lyn-Marié Birkholtz
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
description Here, Reader et al. screen the Medicines for Malaria Venture Pandemic Response Box in parallel against Plasmodiumasexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. They identify two potent transmission-blocking drugs: a histone demethylase inhibitor ML324 and the antitubercular SQ109.
format article
author Janette Reader
Mariëtte E. van der Watt
Dale Taylor
Claire Le Manach
Nimisha Mittal
Sabine Ottilie
Anjo Theron
Phanankosi Moyo
Erica Erlank
Luisa Nardini
Nelius Venter
Sonja Lauterbach
Belinda Bezuidenhout
Andre Horatscheck
Ashleigh van Heerden
Natalie J. Spillman
Anne N. Cowell
Jessica Connacher
Daniel Opperman
Lindsey M. Orchard
Manuel Llinás
Eva S. Istvan
Daniel E. Goldberg
Grant A. Boyle
David Calvo
Dalu Mancama
Theresa L. Coetzer
Elizabeth A. Winzeler
James Duffy
Lizette L. Koekemoer
Gregory Basarab
Kelly Chibale
Lyn-Marié Birkholtz
author_facet Janette Reader
Mariëtte E. van der Watt
Dale Taylor
Claire Le Manach
Nimisha Mittal
Sabine Ottilie
Anjo Theron
Phanankosi Moyo
Erica Erlank
Luisa Nardini
Nelius Venter
Sonja Lauterbach
Belinda Bezuidenhout
Andre Horatscheck
Ashleigh van Heerden
Natalie J. Spillman
Anne N. Cowell
Jessica Connacher
Daniel Opperman
Lindsey M. Orchard
Manuel Llinás
Eva S. Istvan
Daniel E. Goldberg
Grant A. Boyle
David Calvo
Dalu Mancama
Theresa L. Coetzer
Elizabeth A. Winzeler
James Duffy
Lizette L. Koekemoer
Gregory Basarab
Kelly Chibale
Lyn-Marié Birkholtz
author_sort Janette Reader
title Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
title_short Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
title_full Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
title_fullStr Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
title_full_unstemmed Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
title_sort multistage and transmission-blocking targeted antimalarials discovered from the open-source mmv pandemic response box
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/469ad5b32c23403795a07ad1d5fdbabe
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