Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia

Background and Objectives: One major source of antibiotic contamination in the sea is from aquaculture. We monitored the concentration of commonly used antibiotic classes and antibiotic resistance genes (tet(M), sul1, sul2 and sul3) in aquaculture farms in Peninsular Malaysia. Methods: Antibiotic re...

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Autores principales:	Ee Lean Thiang, Choon Weng Lee, Hideshige Takada, Kanako Seki, Ayaka Takei, Satoru Suzuki, Aijun Wang, Chui Wei Bong
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	antibiotic residues resistance genes risk assessment aquaculture Ecology QH540-549.5
Acceso en línea:	https://doaj.org/article/469bddd5a80b4912b62d73dd185524e1
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spelling	oai:doaj.org-article:469bddd5a80b4912b62d73dd185524e12021-12-02T18:04:40ZAntibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia2332-887810.1080/20964129.2021.1926337https://doaj.org/article/469bddd5a80b4912b62d73dd185524e12021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/20964129.2021.1926337https://doaj.org/toc/2332-8878Background and Objectives: One major source of antibiotic contamination in the sea is from aquaculture. We monitored the concentration of commonly used antibiotic classes and antibiotic resistance genes (tet(M), sul1, sul2 and sul3) in aquaculture farms in Peninsular Malaysia. Methods: Antibiotic residues and resistance genes were quantified using high-performance liquid chromatography and real-time PCR respectively. Risk quotients in European technical guidance document on risk assessment was used to assess the potential environmental risk. Results: We detected 23 antibiotics with tetracyclines, sulfonamides and quinolones were the most frequently detected classes, indicating a wide distribution of antibiotics in Malaysian aquaculture farms. The dendrogram and heatmap revealed three groups of antibiotic concentration patterns but with no differences in the types of antibiotics usage among aquaculture farms. The ARGs (10−3 copies/16S) were detected in >90% of the sites except for sul3. Ciprofloxacin, enrofloxacin, norfloxacin and lincomycin posed risks to cyanobacteria and algae in Kelantan, Perak and Pahang. Conclusion: Relative to Asian aquaculture farms, the residues detected here were at low or moderate levels except for quinolones. This study will be useful to develop effective management of aquaculture wastewater in order to mitigate antibiotic pollution and transmission of ARGs to humans through the food chain.Ee Lean ThiangChoon Weng LeeHideshige TakadaKanako SekiAyaka TakeiSatoru SuzukiAijun WangChui Wei BongTaylor & Francis Grouparticleantibiotic residuesresistance genesrisk assessmentaquacultureEcologyQH540-549.5ENEcosystem Health and Sustainability, Vol 7, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic residues resistance genes risk assessment aquaculture Ecology QH540-549.5
spellingShingle	antibiotic residues resistance genes risk assessment aquaculture Ecology QH540-549.5 Ee Lean Thiang Choon Weng Lee Hideshige Takada Kanako Seki Ayaka Takei Satoru Suzuki Aijun Wang Chui Wei Bong Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
description	Background and Objectives: One major source of antibiotic contamination in the sea is from aquaculture. We monitored the concentration of commonly used antibiotic classes and antibiotic resistance genes (tet(M), sul1, sul2 and sul3) in aquaculture farms in Peninsular Malaysia. Methods: Antibiotic residues and resistance genes were quantified using high-performance liquid chromatography and real-time PCR respectively. Risk quotients in European technical guidance document on risk assessment was used to assess the potential environmental risk. Results: We detected 23 antibiotics with tetracyclines, sulfonamides and quinolones were the most frequently detected classes, indicating a wide distribution of antibiotics in Malaysian aquaculture farms. The dendrogram and heatmap revealed three groups of antibiotic concentration patterns but with no differences in the types of antibiotics usage among aquaculture farms. The ARGs (10−3 copies/16S) were detected in >90% of the sites except for sul3. Ciprofloxacin, enrofloxacin, norfloxacin and lincomycin posed risks to cyanobacteria and algae in Kelantan, Perak and Pahang. Conclusion: Relative to Asian aquaculture farms, the residues detected here were at low or moderate levels except for quinolones. This study will be useful to develop effective management of aquaculture wastewater in order to mitigate antibiotic pollution and transmission of ARGs to humans through the food chain.
format	article
author	Ee Lean Thiang Choon Weng Lee Hideshige Takada Kanako Seki Ayaka Takei Satoru Suzuki Aijun Wang Chui Wei Bong
author_facet	Ee Lean Thiang Choon Weng Lee Hideshige Takada Kanako Seki Ayaka Takei Satoru Suzuki Aijun Wang Chui Wei Bong
author_sort	Ee Lean Thiang
title	Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
title_short	Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
title_full	Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
title_fullStr	Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
title_full_unstemmed	Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
title_sort	antibiotic residues from aquaculture farms and their ecological risks in southeast asia: a case study from malaysia
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/469bddd5a80b4912b62d73dd185524e1
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Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia

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