Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome

Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome

ABSTRACT Microbiome studies typically focus on characterizing the taxonomic and functional profiles of the microbes within a community. Functional profiling is generally thought to be superior to taxonomic profiling for investigating human-microbe interactions, but there are several limitations and...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: Morgan G. I. Langille
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
16S
function
human microbiome
metagenomics
taxonomy
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/469c6b7c64b64403b2c0d76295e1ca6e
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:469c6b7c64b64403b2c0d76295e1ca6e
record_format dspace
spelling oai:doaj.org-article:469c6b7c64b64403b2c0d76295e1ca6e2021-12-02T19:47:34ZExploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome10.1128/mSystems.00163-172379-5077https://doaj.org/article/469c6b7c64b64403b2c0d76295e1ca6e2018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00163-17https://doaj.org/toc/2379-5077ABSTRACT Microbiome studies typically focus on characterizing the taxonomic and functional profiles of the microbes within a community. Functional profiling is generally thought to be superior to taxonomic profiling for investigating human-microbe interactions, but there are several limitations and challenges to existing approaches. This Perspective discusses the current sequencing and bioinformatic methods for producing taxonomic and functional profiles, recent studies utilizing and comparing these technologies, and the existing challenges and limitations of these data. In addition, functional versus taxonomic conservation across the population is questioned, while future research that focuses on investigating the taxonomic diversity of microbial functions is proposed.Morgan G. I. LangilleAmerican Society for Microbiologyarticle16Sfunctionhuman microbiomemetagenomicstaxonomyMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution DOAJ
collection DOAJ
language EN
topic 16S
function
human microbiome
metagenomics
taxonomy
Microbiology
QR1-502
spellingShingle 16S
function
human microbiome
metagenomics
taxonomy
Microbiology
QR1-502
Morgan G. I. Langille
Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome
description ABSTRACT Microbiome studies typically focus on characterizing the taxonomic and functional profiles of the microbes within a community. Functional profiling is generally thought to be superior to taxonomic profiling for investigating human-microbe interactions, but there are several limitations and challenges to existing approaches. This Perspective discusses the current sequencing and bioinformatic methods for producing taxonomic and functional profiles, recent studies utilizing and comparing these technologies, and the existing challenges and limitations of these data. In addition, functional versus taxonomic conservation across the population is questioned, while future research that focuses on investigating the taxonomic diversity of microbial functions is proposed.
format article
author Morgan G. I. Langille
author_facet Morgan G. I. Langille
author_sort Morgan G. I. Langille
title Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome
title_short Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome
title_full Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome
title_fullStr Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome
title_full_unstemmed Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome
title_sort exploring linkages between taxonomic and functional profiles of the human microbiome
publisher American Society for Microbiology
publishDate 2018
url https://doaj.org/article/469c6b7c64b64403b2c0d76295e1ca6e
work_keys_str_mv AT morgangilangille exploringlinkagesbetweentaxonomicandfunctionalprofilesofthehumanmicrobiome
_version_ 1718375957673279488

Ejemplares similares