AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation
AMPK activation inhibits cardiac hypertrophy. Here the authors show that this occurs independently of previously proposed mechanisms and that AMPK controls the phosphorylation of the aminotransferase GFAT, thereby preventing cardiac hypertrophy through the reduction of protein O-GlcNAcylation.
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Nature Portfolio
2018
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oai:doaj.org-article:46a09b637dfb42aab34016e0737a3bb62021-12-02T15:33:41ZAMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation10.1038/s41467-017-02795-42041-1723https://doaj.org/article/46a09b637dfb42aab34016e0737a3bb62018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02795-4https://doaj.org/toc/2041-1723AMPK activation inhibits cardiac hypertrophy. Here the authors show that this occurs independently of previously proposed mechanisms and that AMPK controls the phosphorylation of the aminotransferase GFAT, thereby preventing cardiac hypertrophy through the reduction of protein O-GlcNAcylation.Roselle GélinasFlorence MailleuxJustine DontaineLaurent BultotBénédicte DemeulderAudrey GinionEvangelos P. DaskalopoulosHrag EsfahaniEmilie Dubois-DeruyBenjamin LauzierChantal GauthierAaron K. OlsonBertrand BouchardChristine Des RosiersBenoit ViolletKei SakamotoJean-Luc BalligandJean-Louis VanoverscheldeChristophe BeauloyeSandrine HormanLuc BertrandNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Roselle Gélinas Florence Mailleux Justine Dontaine Laurent Bultot Bénédicte Demeulder Audrey Ginion Evangelos P. Daskalopoulos Hrag Esfahani Emilie Dubois-Deruy Benjamin Lauzier Chantal Gauthier Aaron K. Olson Bertrand Bouchard Christine Des Rosiers Benoit Viollet Kei Sakamoto Jean-Luc Balligand Jean-Louis Vanoverschelde Christophe Beauloye Sandrine Horman Luc Bertrand AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation |
| description |
AMPK activation inhibits cardiac hypertrophy. Here the authors show that this occurs independently of previously proposed mechanisms and that AMPK controls the phosphorylation of the aminotransferase GFAT, thereby preventing cardiac hypertrophy through the reduction of protein O-GlcNAcylation. |
| format |
article |
| author |
Roselle Gélinas Florence Mailleux Justine Dontaine Laurent Bultot Bénédicte Demeulder Audrey Ginion Evangelos P. Daskalopoulos Hrag Esfahani Emilie Dubois-Deruy Benjamin Lauzier Chantal Gauthier Aaron K. Olson Bertrand Bouchard Christine Des Rosiers Benoit Viollet Kei Sakamoto Jean-Luc Balligand Jean-Louis Vanoverschelde Christophe Beauloye Sandrine Horman Luc Bertrand |
| author_facet |
Roselle Gélinas Florence Mailleux Justine Dontaine Laurent Bultot Bénédicte Demeulder Audrey Ginion Evangelos P. Daskalopoulos Hrag Esfahani Emilie Dubois-Deruy Benjamin Lauzier Chantal Gauthier Aaron K. Olson Bertrand Bouchard Christine Des Rosiers Benoit Viollet Kei Sakamoto Jean-Luc Balligand Jean-Louis Vanoverschelde Christophe Beauloye Sandrine Horman Luc Bertrand |
| author_sort |
Roselle Gélinas |
| title |
AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation |
| title_short |
AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation |
| title_full |
AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation |
| title_fullStr |
AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation |
| title_full_unstemmed |
AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation |
| title_sort |
ampk activation counteracts cardiac hypertrophy by reducing o-glcnacylation |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/46a09b637dfb42aab34016e0737a3bb6 |
| work_keys_str_mv |
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| _version_ |
1718387020805439488 |