Anti-Human Herpesvirus 6 A/B Antibodies Titers Correlate With Multiple Sclerosis-Associated Retrovirus Envelope Expression

Human endogenous retrovirus W family envelope proteins (pHERV-W ENV/syncytin-1) have been repeatedly associated with multiple sclerosis (MS). Here, we have focused on the study of pHERV-W ENV/syncytin-1 expression levels in MS patients (relapsing and progressive forms) and in healthy donors (HD) and...

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Autores principales:	Silvia Pérez-Pérez, María I. Domínguez-Mozo, M. Ángel García-Martínez, M. Celeste García-Frontini, Noelia Villarrubia, Lucienne Costa-Frossard, Luisa M. Villar, Rafael Arroyo, Roberto Álvarez-Lafuente
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	EBV HERV-W HHV-6A/B multiple sclerosis syncytin-1 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/46a252ddd9464806bccbe145ad267101
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spelling	oai:doaj.org-article:46a252ddd9464806bccbe145ad2671012021-12-01T11:13:20ZAnti-Human Herpesvirus 6 A/B Antibodies Titers Correlate With Multiple Sclerosis-Associated Retrovirus Envelope Expression1664-322410.3389/fimmu.2021.798003https://doaj.org/article/46a252ddd9464806bccbe145ad2671012021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.798003/fullhttps://doaj.org/toc/1664-3224Human endogenous retrovirus W family envelope proteins (pHERV-W ENV/syncytin-1) have been repeatedly associated with multiple sclerosis (MS). Here, we have focused on the study of pHERV-W ENV/syncytin-1 expression levels in MS patients (relapsing and progressive forms) and in healthy donors (HD) and on exploring their possible relationship with Epstein-Barr virus (EBV) and human herpesvirus-6A/B (HHV-6A/B). We included blood samples from 101 MS patients and 37 HD to analyze antiviral antibody titers by ELISA and pHERV-W ENV/syncytin-1 expression levels by flow cytometry as well as by qPCR. Patients with relapsing MS forms showed significantly higher pHERV-W ENV/syncytin-1 protein and gene expression levels than HD. Progressive MS patients also showed significantly higher protein and gene expression levels than both HD and relapsing MS patients. Regarding antiviral antibodies titers, anti-HHV-6A/B IgM levels were positively correlated with pHERV-W ENV/syncytin-1 protein expression levels in patients with relapsing MS, while in the progressive forms patients this correlation was found with anti-HHVA/B IgG levels. Therefore, pHERV-W ENV could be involved in MS pathogenesis, playing a role in relapsing and progressive forms. Besides, anti-HHV-6A/B antibodies positively correlated with pHERV-W ENV expression. Further studies are needed to better understand this possible relationship.Silvia Pérez-PérezMaría I. Domínguez-MozoM. Ángel García-MartínezM. Celeste García-FrontiniNoelia VillarrubiaLucienne Costa-FrossardLuisa M. VillarRafael ArroyoRoberto Álvarez-LafuenteFrontiers Media S.A.articleEBVHERV-WHHV-6A/Bmultiple sclerosissyncytin-1Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	EBV HERV-W HHV-6A/B multiple sclerosis syncytin-1 Immunologic diseases. Allergy RC581-607
spellingShingle	EBV HERV-W HHV-6A/B multiple sclerosis syncytin-1 Immunologic diseases. Allergy RC581-607 Silvia Pérez-Pérez María I. Domínguez-Mozo M. Ángel García-Martínez M. Celeste García-Frontini Noelia Villarrubia Lucienne Costa-Frossard Luisa M. Villar Rafael Arroyo Roberto Álvarez-Lafuente Anti-Human Herpesvirus 6 A/B Antibodies Titers Correlate With Multiple Sclerosis-Associated Retrovirus Envelope Expression
description	Human endogenous retrovirus W family envelope proteins (pHERV-W ENV/syncytin-1) have been repeatedly associated with multiple sclerosis (MS). Here, we have focused on the study of pHERV-W ENV/syncytin-1 expression levels in MS patients (relapsing and progressive forms) and in healthy donors (HD) and on exploring their possible relationship with Epstein-Barr virus (EBV) and human herpesvirus-6A/B (HHV-6A/B). We included blood samples from 101 MS patients and 37 HD to analyze antiviral antibody titers by ELISA and pHERV-W ENV/syncytin-1 expression levels by flow cytometry as well as by qPCR. Patients with relapsing MS forms showed significantly higher pHERV-W ENV/syncytin-1 protein and gene expression levels than HD. Progressive MS patients also showed significantly higher protein and gene expression levels than both HD and relapsing MS patients. Regarding antiviral antibodies titers, anti-HHV-6A/B IgM levels were positively correlated with pHERV-W ENV/syncytin-1 protein expression levels in patients with relapsing MS, while in the progressive forms patients this correlation was found with anti-HHVA/B IgG levels. Therefore, pHERV-W ENV could be involved in MS pathogenesis, playing a role in relapsing and progressive forms. Besides, anti-HHV-6A/B antibodies positively correlated with pHERV-W ENV expression. Further studies are needed to better understand this possible relationship.
format	article
author	Silvia Pérez-Pérez María I. Domínguez-Mozo M. Ángel García-Martínez M. Celeste García-Frontini Noelia Villarrubia Lucienne Costa-Frossard Luisa M. Villar Rafael Arroyo Roberto Álvarez-Lafuente
author_facet	Silvia Pérez-Pérez María I. Domínguez-Mozo M. Ángel García-Martínez M. Celeste García-Frontini Noelia Villarrubia Lucienne Costa-Frossard Luisa M. Villar Rafael Arroyo Roberto Álvarez-Lafuente
author_sort	Silvia Pérez-Pérez
title	Anti-Human Herpesvirus 6 A/B Antibodies Titers Correlate With Multiple Sclerosis-Associated Retrovirus Envelope Expression
title_short	Anti-Human Herpesvirus 6 A/B Antibodies Titers Correlate With Multiple Sclerosis-Associated Retrovirus Envelope Expression
title_full	Anti-Human Herpesvirus 6 A/B Antibodies Titers Correlate With Multiple Sclerosis-Associated Retrovirus Envelope Expression
title_fullStr	Anti-Human Herpesvirus 6 A/B Antibodies Titers Correlate With Multiple Sclerosis-Associated Retrovirus Envelope Expression
title_full_unstemmed	Anti-Human Herpesvirus 6 A/B Antibodies Titers Correlate With Multiple Sclerosis-Associated Retrovirus Envelope Expression
title_sort	anti-human herpesvirus 6 a/b antibodies titers correlate with multiple sclerosis-associated retrovirus envelope expression
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/46a252ddd9464806bccbe145ad267101
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Anti-Human Herpesvirus 6 A/B Antibodies Titers Correlate With Multiple Sclerosis-Associated Retrovirus Envelope Expression

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