Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer

Background: We conducted a meta-analysis to quantitatively assess the association between asbestos exposure and esophageal cancer. Methods: We systematically collected articles from three electronic databases and calculated the pooled standardized mortality rate (SMR) from the meta-analysis. Subgrou...

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Autores principales:	Chih-Wei Wu, Hung-Yi Chuang, Dong-Lin Tsai, Tzu-Yu Kuo, Chen-Cheng Yang, Huang-Chi Chen, Chao-Hung Kuo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	asbestos exposure esophageal cancer carcinogen occupational medicine environmental medicine meta-analysis Medicine R
Acceso en línea:	https://doaj.org/article/46a74d67d0f24b1893e4211b3f5f2447
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spelling	oai:doaj.org-article:46a74d67d0f24b1893e4211b3f5f24472021-11-11T16:14:02ZMeta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer10.3390/ijerph1821110881660-46011661-7827https://doaj.org/article/46a74d67d0f24b1893e4211b3f5f24472021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11088https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Background: We conducted a meta-analysis to quantitatively assess the association between asbestos exposure and esophageal cancer. Methods: We systematically collected articles from three electronic databases and calculated the pooled standardized mortality rate (SMR) from the meta-analysis. Subgroup analysis according to the type of asbestos exposure, follow-up years, sample size, industry classification, sex, and high-dose exposure was conducted. Results: From 242 studies, 34 cohort studies were included in our meta-analysis. Pooled SMR was positively associated with asbestos exposure and esophageal cancer (pooled SMR = 1.28; 95% confidence interval (CI) 1.19–1.38, p < 0.00001). In the subgroup analysis, (1) chrysolite, (2) four groups with follow-up over ten years, (3) the textile industry and shipyard, (4) both male and female, and (5) eight studies on highest asbestos exposure, all the subgroups showed significantly increased pooled SMRs. Conclusion: Asbestos exposure was significantly and positively associated with esophageal cancer, especially chrysolite. Considering the long latency period, we suggest that patients should be followed up for cancer, including esophageal cancer, for over ten years.Chih-Wei WuHung-Yi ChuangDong-Lin TsaiTzu-Yu KuoChen-Cheng YangHuang-Chi ChenChao-Hung KuoMDPI AGarticleasbestos exposureesophageal cancercarcinogenoccupational medicineenvironmental medicinemeta-analysisMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11088, p 11088 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	asbestos exposure esophageal cancer carcinogen occupational medicine environmental medicine meta-analysis Medicine R
spellingShingle	asbestos exposure esophageal cancer carcinogen occupational medicine environmental medicine meta-analysis Medicine R Chih-Wei Wu Hung-Yi Chuang Dong-Lin Tsai Tzu-Yu Kuo Chen-Cheng Yang Huang-Chi Chen Chao-Hung Kuo Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer
description	Background: We conducted a meta-analysis to quantitatively assess the association between asbestos exposure and esophageal cancer. Methods: We systematically collected articles from three electronic databases and calculated the pooled standardized mortality rate (SMR) from the meta-analysis. Subgroup analysis according to the type of asbestos exposure, follow-up years, sample size, industry classification, sex, and high-dose exposure was conducted. Results: From 242 studies, 34 cohort studies were included in our meta-analysis. Pooled SMR was positively associated with asbestos exposure and esophageal cancer (pooled SMR = 1.28; 95% confidence interval (CI) 1.19–1.38, p < 0.00001). In the subgroup analysis, (1) chrysolite, (2) four groups with follow-up over ten years, (3) the textile industry and shipyard, (4) both male and female, and (5) eight studies on highest asbestos exposure, all the subgroups showed significantly increased pooled SMRs. Conclusion: Asbestos exposure was significantly and positively associated with esophageal cancer, especially chrysolite. Considering the long latency period, we suggest that patients should be followed up for cancer, including esophageal cancer, for over ten years.
format	article
author	Chih-Wei Wu Hung-Yi Chuang Dong-Lin Tsai Tzu-Yu Kuo Chen-Cheng Yang Huang-Chi Chen Chao-Hung Kuo
author_facet	Chih-Wei Wu Hung-Yi Chuang Dong-Lin Tsai Tzu-Yu Kuo Chen-Cheng Yang Huang-Chi Chen Chao-Hung Kuo
author_sort	Chih-Wei Wu
title	Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer
title_short	Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer
title_full	Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer
title_fullStr	Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer
title_full_unstemmed	Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer
title_sort	meta-analysis of the association between asbestos exposure and esophageal cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/46a74d67d0f24b1893e4211b3f5f2447
work_keys_str_mv	AT chihweiwu metaanalysisoftheassociationbetweenasbestosexposureandesophagealcancer AT hungyichuang metaanalysisoftheassociationbetweenasbestosexposureandesophagealcancer AT donglintsai metaanalysisoftheassociationbetweenasbestosexposureandesophagealcancer AT tzuyukuo metaanalysisoftheassociationbetweenasbestosexposureandesophagealcancer AT chenchengyang metaanalysisoftheassociationbetweenasbestosexposureandesophagealcancer AT huangchichen metaanalysisoftheassociationbetweenasbestosexposureandesophagealcancer AT chaohungkuo metaanalysisoftheassociationbetweenasbestosexposureandesophagealcancer
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Meta-Analysis of the Association between Asbestos Exposure and Esophageal Cancer

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