Characterization of an In Vivo Neutralizing Anti-Vaccinia Virus D8 Single-Chain Fragment Variable (scFv) from a Human Anti-Vaccinia Virus-Specific Recombinant Library

Characterization of an In Vivo Neutralizing Anti-Vaccinia Virus D8 Single-Chain Fragment Variable (scFv) from a Human Anti-Vaccinia Virus-Specific Recombinant Library

A panel of potent neutralizing antibodies are protective against orthopoxvirus (OPXV) infections. For the development of OPXV-specific recombinant human single-chain antibodies (scFvs), the IgG repertoire of four vaccinated donors was amplified from peripheral B-lymphocytes. The resulting library co...

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Autores principales: Ulrike S. Diesterbeck, Henrike P. Ahsendorf, André Frenzel, Ahmad Reza Sharifi, Thomas Schirrmann, Claus-Peter Czerny
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
scFv
vaccinia virus
recombinant antibody
D8
Medicine
R
Acceso en línea:https://doaj.org/article/46ac0221921e4932ad936734ce702782
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