The role of vascular complexity on optimal junction exponents

Abstract We examine the role of complexity on arterial tree structures, determining globally optimal vessel arrangements using the Simulated AnneaLing Vascular Optimization algorithm, a computational method which we have previously used to reproduce features of cardiac and cerebral vasculatures. In...

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Autores principales:	Jonathan Keelan, James P. Hague
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/46aeea74f1734443b1684a62ad7a928e
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spelling	oai:doaj.org-article:46aeea74f1734443b1684a62ad7a928e2021-12-02T13:34:46ZThe role of vascular complexity on optimal junction exponents10.1038/s41598-021-84432-12045-2322https://doaj.org/article/46aeea74f1734443b1684a62ad7a928e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84432-1https://doaj.org/toc/2045-2322Abstract We examine the role of complexity on arterial tree structures, determining globally optimal vessel arrangements using the Simulated AnneaLing Vascular Optimization algorithm, a computational method which we have previously used to reproduce features of cardiac and cerebral vasculatures. In order to progress computational methods for growing arterial networks, deeper understanding of the stability of computational arterial growth algorithms to complexity, variations in physiological parameters (such as metabolic costs for maintaining and pumping blood), and underlying assumptions regarding the value of junction exponents is needed. We determine the globally optimal structure of two-dimensional arterial trees; analysing how physiological parameters affect tree morphology and optimal bifurcation exponent. We find that considering the full complexity of arterial trees is essential for determining the fundamental properties of vasculatures. We conclude that optimisation-based arterial growth algorithms are stable against uncertainties in physiological parameters, while optimal bifurcation exponents (a key parameter for many arterial growth algorithms) are affected by the complexity of vascular networks and the boundary conditions dictated by organs.Jonathan KeelanJames P. HagueNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jonathan Keelan James P. Hague The role of vascular complexity on optimal junction exponents
description	Abstract We examine the role of complexity on arterial tree structures, determining globally optimal vessel arrangements using the Simulated AnneaLing Vascular Optimization algorithm, a computational method which we have previously used to reproduce features of cardiac and cerebral vasculatures. In order to progress computational methods for growing arterial networks, deeper understanding of the stability of computational arterial growth algorithms to complexity, variations in physiological parameters (such as metabolic costs for maintaining and pumping blood), and underlying assumptions regarding the value of junction exponents is needed. We determine the globally optimal structure of two-dimensional arterial trees; analysing how physiological parameters affect tree morphology and optimal bifurcation exponent. We find that considering the full complexity of arterial trees is essential for determining the fundamental properties of vasculatures. We conclude that optimisation-based arterial growth algorithms are stable against uncertainties in physiological parameters, while optimal bifurcation exponents (a key parameter for many arterial growth algorithms) are affected by the complexity of vascular networks and the boundary conditions dictated by organs.
format	article
author	Jonathan Keelan James P. Hague
author_facet	Jonathan Keelan James P. Hague
author_sort	Jonathan Keelan
title	The role of vascular complexity on optimal junction exponents
title_short	The role of vascular complexity on optimal junction exponents
title_full	The role of vascular complexity on optimal junction exponents
title_fullStr	The role of vascular complexity on optimal junction exponents
title_full_unstemmed	The role of vascular complexity on optimal junction exponents
title_sort	role of vascular complexity on optimal junction exponents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/46aeea74f1734443b1684a62ad7a928e
work_keys_str_mv	AT jonathankeelan theroleofvascularcomplexityonoptimaljunctionexponents AT jamesphague theroleofvascularcomplexityonoptimaljunctionexponents AT jonathankeelan roleofvascularcomplexityonoptimaljunctionexponents AT jamesphague roleofvascularcomplexityonoptimaljunctionexponents
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The role of vascular complexity on optimal junction exponents

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