Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank
BackgroundThe triglyceride-glucose (TyG) index is a practical substitute measure for insulin resistance (IR). The relationship between IR and lung cancer has been examined in previous studies; however, the findings have been controversial. In addition, previous studies had small sample sizes. Thus,...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:46af443737794acba6441bc59fedffd02021-11-17T05:11:13ZTriglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank2234-943X10.3389/fonc.2021.774937https://doaj.org/article/46af443737794acba6441bc59fedffd02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.774937/fullhttps://doaj.org/toc/2234-943XBackgroundThe triglyceride-glucose (TyG) index is a practical substitute measure for insulin resistance (IR). The relationship between IR and lung cancer has been examined in previous studies; however, the findings have been controversial. In addition, previous studies had small sample sizes. Thus, we systematically examined the association between IR and lung cancer risk based on the UK Biobank with IR measured by the TyG index and further examined the interactions and joint effects for lung cancer.MethodsA total of 324,334 individuals free from any type of cancer at recruitment from the UK Biobank prospective cohort were included. The participants were predominantly between 40 and 70 years old. After adjusting for relevant confounders, multivariable Cox regression models were constructed to examine the relationship between the TyG index and the risk of lung cancer. We also checked the interactions and joint effects using a polygenic risk score (PRS) for lung cancer.ResultsDuring a median follow-up of 9 years, 1,593 individuals were diagnosed with lung cancer. No association was found between the TyG index and lung cancer risk after multivariate Cox regression analysis adjusted for risk factors (hazard ratio: 0.91; 95% confidence interval: 0.64–1.18). No interaction or joint effects for genetic risk and the TyG index were observed.ConclusionThe TyG index was not associated with the risk of lung cancer. Our results provide limited evidence that IR is not correlated with the risk of lung cancer.Lijie WangLijie WangShucheng SiShucheng SiJiqing LiJiqing LiYunxia LiYunxia LiXiaolu ChenXiaolu ChenFuzhong XueFuzhong XueWangang RenFrontiers Media S.A.articlelung cancerinsulin resistanceUK Biobanklongitudinal studytriglyceride-glucose indexNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
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EN |
| topic |
lung cancer insulin resistance UK Biobank longitudinal study triglyceride-glucose index Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
lung cancer insulin resistance UK Biobank longitudinal study triglyceride-glucose index Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lijie Wang Lijie Wang Shucheng Si Shucheng Si Jiqing Li Jiqing Li Yunxia Li Yunxia Li Xiaolu Chen Xiaolu Chen Fuzhong Xue Fuzhong Xue Wangang Ren Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank |
| description |
BackgroundThe triglyceride-glucose (TyG) index is a practical substitute measure for insulin resistance (IR). The relationship between IR and lung cancer has been examined in previous studies; however, the findings have been controversial. In addition, previous studies had small sample sizes. Thus, we systematically examined the association between IR and lung cancer risk based on the UK Biobank with IR measured by the TyG index and further examined the interactions and joint effects for lung cancer.MethodsA total of 324,334 individuals free from any type of cancer at recruitment from the UK Biobank prospective cohort were included. The participants were predominantly between 40 and 70 years old. After adjusting for relevant confounders, multivariable Cox regression models were constructed to examine the relationship between the TyG index and the risk of lung cancer. We also checked the interactions and joint effects using a polygenic risk score (PRS) for lung cancer.ResultsDuring a median follow-up of 9 years, 1,593 individuals were diagnosed with lung cancer. No association was found between the TyG index and lung cancer risk after multivariate Cox regression analysis adjusted for risk factors (hazard ratio: 0.91; 95% confidence interval: 0.64–1.18). No interaction or joint effects for genetic risk and the TyG index were observed.ConclusionThe TyG index was not associated with the risk of lung cancer. Our results provide limited evidence that IR is not correlated with the risk of lung cancer. |
| format |
article |
| author |
Lijie Wang Lijie Wang Shucheng Si Shucheng Si Jiqing Li Jiqing Li Yunxia Li Yunxia Li Xiaolu Chen Xiaolu Chen Fuzhong Xue Fuzhong Xue Wangang Ren |
| author_facet |
Lijie Wang Lijie Wang Shucheng Si Shucheng Si Jiqing Li Jiqing Li Yunxia Li Yunxia Li Xiaolu Chen Xiaolu Chen Fuzhong Xue Fuzhong Xue Wangang Ren |
| author_sort |
Lijie Wang |
| title |
Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank |
| title_short |
Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank |
| title_full |
Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank |
| title_fullStr |
Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank |
| title_full_unstemmed |
Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank |
| title_sort |
triglyceride-glucose index is not associated with lung cancer risk: a prospective cohort study in the uk biobank |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/46af443737794acba6441bc59fedffd0 |
| work_keys_str_mv |
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