A preliminary study of bowel rest strategy in the management of Clostridioides difficile infection

Abstract Clostridioides difficile infection (CDI) is an important nosocomial infection and is the leading cause of infectious diarrhea in hospitalized patients. We aimed to assess the effect of bowel rest on the management of CDI. A single-center retrospective cohort study was conducted. The primary...

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Autores principales:	Hiroshi Sugimoto, Ayaka Yoshihara, Takao Yamamoto, Keisuke Sugimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/46b0d5b79481457db9c1d599c1e84665
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spelling	oai:doaj.org-article:46b0d5b79481457db9c1d599c1e846652021-12-02T12:42:27ZA preliminary study of bowel rest strategy in the management of Clostridioides difficile infection10.1038/s41598-020-79211-32045-2322https://doaj.org/article/46b0d5b79481457db9c1d599c1e846652020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79211-3https://doaj.org/toc/2045-2322Abstract Clostridioides difficile infection (CDI) is an important nosocomial infection and is the leading cause of infectious diarrhea in hospitalized patients. We aimed to assess the effect of bowel rest on the management of CDI. A single-center retrospective cohort study was conducted. The primary outcome was the composite of the all-cause mortality and CDI recurrence within 30 days. The main secondary outcome was switching from metronidazole to vancomycin. Of the 91 patients with CDI enrolled as the full cohort, 63 patients (69%) and 28 patients (31%) constituted the control group and the bowel rest group, respectively. After one-to-one propensity score matching, a total of 46 patients were included as the matched cohort. In the full cohort, the composite outcome occurred in 19.0% and 14.3% of the patients in the control and the bowel rest group, respectively (p = 0.768). In the matched cohort, it was 17.4% in each group. Although there was no statistically significant difference, the trend of switching was lower in the bowel rest group. The bowel rest may not affect the all-cause mortality and CDI recurrence within 30 days. However, in those prescribed bowel rest, switching from metronidazole to vancomycin may reduce.Hiroshi SugimotoAyaka YoshiharaTakao YamamotoKeisuke SugimotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroshi Sugimoto Ayaka Yoshihara Takao Yamamoto Keisuke Sugimoto A preliminary study of bowel rest strategy in the management of Clostridioides difficile infection
description	Abstract Clostridioides difficile infection (CDI) is an important nosocomial infection and is the leading cause of infectious diarrhea in hospitalized patients. We aimed to assess the effect of bowel rest on the management of CDI. A single-center retrospective cohort study was conducted. The primary outcome was the composite of the all-cause mortality and CDI recurrence within 30 days. The main secondary outcome was switching from metronidazole to vancomycin. Of the 91 patients with CDI enrolled as the full cohort, 63 patients (69%) and 28 patients (31%) constituted the control group and the bowel rest group, respectively. After one-to-one propensity score matching, a total of 46 patients were included as the matched cohort. In the full cohort, the composite outcome occurred in 19.0% and 14.3% of the patients in the control and the bowel rest group, respectively (p = 0.768). In the matched cohort, it was 17.4% in each group. Although there was no statistically significant difference, the trend of switching was lower in the bowel rest group. The bowel rest may not affect the all-cause mortality and CDI recurrence within 30 days. However, in those prescribed bowel rest, switching from metronidazole to vancomycin may reduce.
format	article
author	Hiroshi Sugimoto Ayaka Yoshihara Takao Yamamoto Keisuke Sugimoto
author_facet	Hiroshi Sugimoto Ayaka Yoshihara Takao Yamamoto Keisuke Sugimoto
author_sort	Hiroshi Sugimoto
title	A preliminary study of bowel rest strategy in the management of Clostridioides difficile infection
title_short	A preliminary study of bowel rest strategy in the management of Clostridioides difficile infection
title_full	A preliminary study of bowel rest strategy in the management of Clostridioides difficile infection
title_fullStr	A preliminary study of bowel rest strategy in the management of Clostridioides difficile infection
title_full_unstemmed	A preliminary study of bowel rest strategy in the management of Clostridioides difficile infection
title_sort	preliminary study of bowel rest strategy in the management of clostridioides difficile infection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/46b0d5b79481457db9c1d599c1e84665
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A preliminary study of bowel rest strategy in the management of Clostridioides difficile infection

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