ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs
Understanding how SARS-CoV-2 gains initial entry into the human body is a key step towards the development of prophylaxes and therapeutics for COVID-19. Here, the authors show that ACE2, the receptor for SARS-CoV-2, is abundantly expressed in the motile cilia of the human nasal and respiratory tract...
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Nature Portfolio
2020
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oai:doaj.org-article:46b19154257e4119b14a2d65b124b2f32021-12-02T14:40:52ZACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs10.1038/s41467-020-19145-62041-1723https://doaj.org/article/46b19154257e4119b14a2d65b124b2f32020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19145-6https://doaj.org/toc/2041-1723Understanding how SARS-CoV-2 gains initial entry into the human body is a key step towards the development of prophylaxes and therapeutics for COVID-19. Here, the authors show that ACE2, the receptor for SARS-CoV-2, is abundantly expressed in the motile cilia of the human nasal and respiratory tract and is not affected by the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers.Ivan T. LeeTsuguhisa NakayamaChien-Ting WuYury GoltsevSizun JiangPhillip A. GallChun-Kang LiaoLiang-Chun ShihChristian M. SchürchDavid R. McIlwainPauline ChuNicole A. BorchardDavid ZarabandaSachi S. DholakiaAngela YangDayoung KimHan ChenTomoharu KanieChia-Der LinMing-Hsui TsaiKatie M. PhillipsRaymond KimJonathan B. OverdevestMatthew A. TylerCarol H. YanChih-Feng LinYi-Tsen LinDa-Tian BauGregory J. TsayZara M. PatelYung-An TsouAlexandar TzankovMatthias S. MatterChih-Jaan TaiTe-Huei YehPeter H. HwangGarry P. NolanJayakar V. NayakPeter K. JacksonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ivan T. Lee Tsuguhisa Nakayama Chien-Ting Wu Yury Goltsev Sizun Jiang Phillip A. Gall Chun-Kang Liao Liang-Chun Shih Christian M. Schürch David R. McIlwain Pauline Chu Nicole A. Borchard David Zarabanda Sachi S. Dholakia Angela Yang Dayoung Kim Han Chen Tomoharu Kanie Chia-Der Lin Ming-Hsui Tsai Katie M. Phillips Raymond Kim Jonathan B. Overdevest Matthew A. Tyler Carol H. Yan Chih-Feng Lin Yi-Tsen Lin Da-Tian Bau Gregory J. Tsay Zara M. Patel Yung-An Tsou Alexandar Tzankov Matthias S. Matter Chih-Jaan Tai Te-Huei Yeh Peter H. Hwang Garry P. Nolan Jayakar V. Nayak Peter K. Jackson ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs |
| description |
Understanding how SARS-CoV-2 gains initial entry into the human body is a key step towards the development of prophylaxes and therapeutics for COVID-19. Here, the authors show that ACE2, the receptor for SARS-CoV-2, is abundantly expressed in the motile cilia of the human nasal and respiratory tract and is not affected by the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. |
| format |
article |
| author |
Ivan T. Lee Tsuguhisa Nakayama Chien-Ting Wu Yury Goltsev Sizun Jiang Phillip A. Gall Chun-Kang Liao Liang-Chun Shih Christian M. Schürch David R. McIlwain Pauline Chu Nicole A. Borchard David Zarabanda Sachi S. Dholakia Angela Yang Dayoung Kim Han Chen Tomoharu Kanie Chia-Der Lin Ming-Hsui Tsai Katie M. Phillips Raymond Kim Jonathan B. Overdevest Matthew A. Tyler Carol H. Yan Chih-Feng Lin Yi-Tsen Lin Da-Tian Bau Gregory J. Tsay Zara M. Patel Yung-An Tsou Alexandar Tzankov Matthias S. Matter Chih-Jaan Tai Te-Huei Yeh Peter H. Hwang Garry P. Nolan Jayakar V. Nayak Peter K. Jackson |
| author_facet |
Ivan T. Lee Tsuguhisa Nakayama Chien-Ting Wu Yury Goltsev Sizun Jiang Phillip A. Gall Chun-Kang Liao Liang-Chun Shih Christian M. Schürch David R. McIlwain Pauline Chu Nicole A. Borchard David Zarabanda Sachi S. Dholakia Angela Yang Dayoung Kim Han Chen Tomoharu Kanie Chia-Der Lin Ming-Hsui Tsai Katie M. Phillips Raymond Kim Jonathan B. Overdevest Matthew A. Tyler Carol H. Yan Chih-Feng Lin Yi-Tsen Lin Da-Tian Bau Gregory J. Tsay Zara M. Patel Yung-An Tsou Alexandar Tzankov Matthias S. Matter Chih-Jaan Tai Te-Huei Yeh Peter H. Hwang Garry P. Nolan Jayakar V. Nayak Peter K. Jackson |
| author_sort |
Ivan T. Lee |
| title |
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs |
| title_short |
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs |
| title_full |
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs |
| title_fullStr |
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs |
| title_full_unstemmed |
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs |
| title_sort |
ace2 localizes to the respiratory cilia and is not increased by ace inhibitors or arbs |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/46b19154257e4119b14a2d65b124b2f3 |
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