Reversible global aphasia as a side effect of quetiapine: a case report and literature review

Ching-Fang Chien,1 Poyin Huang,1,2 Sun-Wung Hsieh1,2 1Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 2Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan Abstract: Quetiapine is an atypical antipsychotic agent which is also prescr...

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Autores principales:	Chien CF, Huang P, Hsieh SW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	aphasia quetiapine insomnia delirium Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/46b2e9b593984e9391cea072d859ea6a
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spelling	oai:doaj.org-article:46b2e9b593984e9391cea072d859ea6a2021-12-02T00:33:51ZReversible global aphasia as a side effect of quetiapine: a case report and literature review1178-2021https://doaj.org/article/46b2e9b593984e9391cea072d859ea6a2017-08-01T00:00:00Zhttps://www.dovepress.com/reversible-global-aphasia-as-a-side-effect-of-quetiapine-a-case-report-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ching-Fang Chien,1 Poyin Huang,1,2 Sun-Wung Hsieh1,2 1Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 2Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan Abstract: Quetiapine is an atypical antipsychotic agent which is also prescribed for delirium due to its anti-dopaminergic effects; aphasia is an unusual side effect associated with the drug. Here, we report the case of an 83-year-old woman who was prescribed quetiapine (50 mg per day) for delirium. Unexpected, global aphasia occurred 3 days after treatment began. Complete recovery occurred following discontinuation of the drug. A brain computed tomography scan excluded intracranial hemorrhage and the laboratory results confirmed that no exacerbation of infection or electrolyte imbalances were present. During the aphasic episode, the patient’s condition did not deteriorate and no new neurological symptoms occurred. We suspect that the occurrence of aphasia was directly due to an adverse reaction to quetiapine. To our knowledge, this is the first case report of reversible, global aphasia as a side effect of quetiapine. We propose that this occurrence of aphasia may be due to the action of quetiapine as a dopamine receptor antagonist. Clinicians should use quetiapine with caution, especially in elderly patients. On observation of aphasia, a review of the patient’s medical history is required to assess for the usage of quetiapine. Keywords: aphasia, quetiapine, insomnia, deliriumChien CFHuang PHsieh SWDove Medical PressarticleaphasiaquetiapineinsomniadeliriumNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2257-2260 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	aphasia quetiapine insomnia delirium Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	aphasia quetiapine insomnia delirium Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chien CF Huang P Hsieh SW Reversible global aphasia as a side effect of quetiapine: a case report and literature review
description	Ching-Fang Chien,1 Poyin Huang,1,2 Sun-Wung Hsieh1,2 1Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 2Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan Abstract: Quetiapine is an atypical antipsychotic agent which is also prescribed for delirium due to its anti-dopaminergic effects; aphasia is an unusual side effect associated with the drug. Here, we report the case of an 83-year-old woman who was prescribed quetiapine (50 mg per day) for delirium. Unexpected, global aphasia occurred 3 days after treatment began. Complete recovery occurred following discontinuation of the drug. A brain computed tomography scan excluded intracranial hemorrhage and the laboratory results confirmed that no exacerbation of infection or electrolyte imbalances were present. During the aphasic episode, the patient’s condition did not deteriorate and no new neurological symptoms occurred. We suspect that the occurrence of aphasia was directly due to an adverse reaction to quetiapine. To our knowledge, this is the first case report of reversible, global aphasia as a side effect of quetiapine. We propose that this occurrence of aphasia may be due to the action of quetiapine as a dopamine receptor antagonist. Clinicians should use quetiapine with caution, especially in elderly patients. On observation of aphasia, a review of the patient’s medical history is required to assess for the usage of quetiapine. Keywords: aphasia, quetiapine, insomnia, delirium
format	article
author	Chien CF Huang P Hsieh SW
author_facet	Chien CF Huang P Hsieh SW
author_sort	Chien CF
title	Reversible global aphasia as a side effect of quetiapine: a case report and literature review
title_short	Reversible global aphasia as a side effect of quetiapine: a case report and literature review
title_full	Reversible global aphasia as a side effect of quetiapine: a case report and literature review
title_fullStr	Reversible global aphasia as a side effect of quetiapine: a case report and literature review
title_full_unstemmed	Reversible global aphasia as a side effect of quetiapine: a case report and literature review
title_sort	reversible global aphasia as a side effect of quetiapine: a case report and literature review
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/46b2e9b593984e9391cea072d859ea6a
work_keys_str_mv	AT chiencf reversibleglobalaphasiaasasideeffectofquetiapineacasereportandliteraturereview AT huangp reversibleglobalaphasiaasasideeffectofquetiapineacasereportandliteraturereview AT hsiehsw reversibleglobalaphasiaasasideeffectofquetiapineacasereportandliteraturereview
_version_	1718403612658368512

Reversible global aphasia as a side effect of quetiapine: a case report and literature review

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