G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning

G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning

Abstract Biased agonism at G protein coupled receptors emerges as an opportunity for development of drugs with enhanced benefit/risk balance making biased ligand identification a priority. However, ligand biased signature, classically inferred from ligand activity across multiple pathways, displays...

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Autores principales: Lauriane Onfroy, Ségolène Galandrin, Stéphanie M. Pontier, Marie-Hélène Seguelas, Du N’Guyen, Jean-Michel Sénard, Céline Galés
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/46b62063d1b048b08dc910da43acf68d
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