Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts

Selenoproteins containing selenium have a variety of physiological functions including redox homeostasis and thyroid hormone metabolism. Here, the authors show that RANKL-dependent repression of selenoprotein W regulates cell fusion during osteoclast differentiation and bone remodelling in mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyunsoo Kim, Kyunghee Lee, Jin Man Kim, Mi Yeong Kim, Jae-Ryong Kim, Han-Woong Lee, Youn Wook Chung, Hong-In Shin, Taesoo Kim, Eui-Soon Park, Jaerang Rho, Seoung Hoon Lee, Nacksung Kim, Soo Young Lee, Yongwon Choi, Daewon Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/46b6d838118746ec9a1733c8cc6e016a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:46b6d838118746ec9a1733c8cc6e016a
record_format	dspace
spelling	oai:doaj.org-article:46b6d838118746ec9a1733c8cc6e016a2021-12-02T14:30:26ZSelenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts10.1038/s41467-021-22565-72041-1723https://doaj.org/article/46b6d838118746ec9a1733c8cc6e016a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22565-7https://doaj.org/toc/2041-1723Selenoproteins containing selenium have a variety of physiological functions including redox homeostasis and thyroid hormone metabolism. Here, the authors show that RANKL-dependent repression of selenoprotein W regulates cell fusion during osteoclast differentiation and bone remodelling in mice.Hyunsoo KimKyunghee LeeJin Man KimMi Yeong KimJae-Ryong KimHan-Woong LeeYoun Wook ChungHong-In ShinTaesoo KimEui-Soon ParkJaerang RhoSeoung Hoon LeeNacksung KimSoo Young LeeYongwon ChoiDaewon JeongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyunsoo Kim Kyunghee Lee Jin Man Kim Mi Yeong Kim Jae-Ryong Kim Han-Woong Lee Youn Wook Chung Hong-In Shin Taesoo Kim Eui-Soon Park Jaerang Rho Seoung Hoon Lee Nacksung Kim Soo Young Lee Yongwon Choi Daewon Jeong Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
description	Selenoproteins containing selenium have a variety of physiological functions including redox homeostasis and thyroid hormone metabolism. Here, the authors show that RANKL-dependent repression of selenoprotein W regulates cell fusion during osteoclast differentiation and bone remodelling in mice.
format	article
author	Hyunsoo Kim Kyunghee Lee Jin Man Kim Mi Yeong Kim Jae-Ryong Kim Han-Woong Lee Youn Wook Chung Hong-In Shin Taesoo Kim Eui-Soon Park Jaerang Rho Seoung Hoon Lee Nacksung Kim Soo Young Lee Yongwon Choi Daewon Jeong
author_facet	Hyunsoo Kim Kyunghee Lee Jin Man Kim Mi Yeong Kim Jae-Ryong Kim Han-Woong Lee Youn Wook Chung Hong-In Shin Taesoo Kim Eui-Soon Park Jaerang Rho Seoung Hoon Lee Nacksung Kim Soo Young Lee Yongwon Choi Daewon Jeong
author_sort	Hyunsoo Kim
title	Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
title_short	Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
title_full	Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
title_fullStr	Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
title_full_unstemmed	Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
title_sort	selenoprotein w ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/46b6d838118746ec9a1733c8cc6e016a
work_keys_str_mv	AT hyunsookim selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT kyungheelee selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT jinmankim selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT miyeongkim selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT jaeryongkim selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT hanwoonglee selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT younwookchung selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT honginshin selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT taesookim selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT euisoonpark selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT jaerangrho selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT seounghoonlee selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT nacksungkim selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT sooyounglee selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT yongwonchoi selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts AT daewonjeong selenoproteinwensuresphysiologicalboneremodelingbypreventinghyperactivityofosteoclasts
_version_	1718391187039059968

Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts

Ejemplares similares