Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
Selenoproteins containing selenium have a variety of physiological functions including redox homeostasis and thyroid hormone metabolism. Here, the authors show that RANKL-dependent repression of selenoprotein W regulates cell fusion during osteoclast differentiation and bone remodelling in mice.
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Autores principales: | Hyunsoo Kim, Kyunghee Lee, Jin Man Kim, Mi Yeong Kim, Jae-Ryong Kim, Han-Woong Lee, Youn Wook Chung, Hong-In Shin, Taesoo Kim, Eui-Soon Park, Jaerang Rho, Seoung Hoon Lee, Nacksung Kim, Soo Young Lee, Yongwon Choi, Daewon Jeong |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/46b6d838118746ec9a1733c8cc6e016a |
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