PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway

Abstract Reprogramming of adult somatic cells into induced pluripotent stem cells holds great promise in clinical therapy. Increasing evidences have shown that p53 and its target genes play important roles in somatic cell reprogramming. In this study, we report that PHLDA3, a p53 target gene, functi...

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Autores principales:	Mengran Qiao, Mian Wu, Ronghua Shi, Wanglai Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/46b8c69175644bd1a57a0477d1d5901d
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spelling	oai:doaj.org-article:46b8c69175644bd1a57a0477d1d5901d2021-12-02T16:07:57ZPHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway10.1038/s41598-017-02982-92045-2322https://doaj.org/article/46b8c69175644bd1a57a0477d1d5901d2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02982-9https://doaj.org/toc/2045-2322Abstract Reprogramming of adult somatic cells into induced pluripotent stem cells holds great promise in clinical therapy. Increasing evidences have shown that p53 and its target genes play important roles in somatic cell reprogramming. In this study, we report that PHLDA3, a p53 target gene, functions as a blockage of iPSCs generation by activating the Akt-GSK3β pathway. Furthermore, PHLDA3 is found to be transcriptionally regulated by Oct4. These findings reveal that PHLDA3 acts as a new member of the regulatory network of somatic cell reprogramming.Mengran QiaoMian WuRonghua ShiWanglai HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mengran Qiao Mian Wu Ronghua Shi Wanglai Hu PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
description	Abstract Reprogramming of adult somatic cells into induced pluripotent stem cells holds great promise in clinical therapy. Increasing evidences have shown that p53 and its target genes play important roles in somatic cell reprogramming. In this study, we report that PHLDA3, a p53 target gene, functions as a blockage of iPSCs generation by activating the Akt-GSK3β pathway. Furthermore, PHLDA3 is found to be transcriptionally regulated by Oct4. These findings reveal that PHLDA3 acts as a new member of the regulatory network of somatic cell reprogramming.
format	article
author	Mengran Qiao Mian Wu Ronghua Shi Wanglai Hu
author_facet	Mengran Qiao Mian Wu Ronghua Shi Wanglai Hu
author_sort	Mengran Qiao
title	PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
title_short	PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
title_full	PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
title_fullStr	PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
title_full_unstemmed	PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
title_sort	phlda3 impedes somatic cell reprogramming by activating akt-gsk3β pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/46b8c69175644bd1a57a0477d1d5901d
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PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway

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