FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.

The Alzheimer disease (AD) amyloid protein precursor (APP) can bind the FE65 adaptor protein and this complex can regulate gene expression. We carried out yeast two-hybrid studies with a PTB domain of FE65, focusing on those genes that might be involved in nuclear signaling, and identified and valid...

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Auteurs principaux: Yuji Kajiwara, Afia Akram, Pavel Katsel, Vahram Haroutunian, James Schmeidler, Gary Beecham, Jonathan L Haines, Margaret A Pericak-Vance, Joseph D Buxbaum
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2009
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R
Q
Accès en ligne:https://doaj.org/article/46b9023f00914bcca4c317ff211da94c
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