RE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity

Alberto Mavilio,1 Dario Sisto,2 Paolo Ferreri,2 Nicola Cardascia,2 Giovanni Alessio2 1Social Health District, Glaucoma Center, Azienda Sanitaria Locale, Brindisi, 2Department of Ophthalmology and Otolaryngology, University of Bari, Bari, Italy Purpose: A significant variability of the second harmo...

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Autores principales:	Mavilio A, Sisto D, Ferreri P, Cardascia N, Alessio G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	glaucoma pattern electroretinogram optical coherence tomography ganglion cells visual field Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/46bb1d875fd14648818446eace436491
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spelling	oai:doaj.org-article:46bb1d875fd14648818446eace4364912021-12-02T02:06:05ZRE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity1177-5483https://doaj.org/article/46bb1d875fd14648818446eace4364912017-01-01T00:00:00Zhttps://www.dovepress.com/re-perg-a-new-procedure-for-electrophysiologic-diagnosis-of-glaucoma-t-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Alberto Mavilio,1 Dario Sisto,2 Paolo Ferreri,2 Nicola Cardascia,2 Giovanni Alessio2 1Social Health District, Glaucoma Center, Azienda Sanitaria Locale, Brindisi, 2Department of Ophthalmology and Otolaryngology, University of Bari, Bari, Italy Purpose: A significant variability of the second harmonic (2ndH) phase of steady-state pattern electroretinogram (SS-PERG) in intrasession retest has been recently described in glaucoma patients (GP), which has not been found in healthy subjects. To evaluate the reliability of phase variability in retest (a procedure called RE-PERG or REPERG) in the presence of cataract, which is known to affect standard PERG, we tested this procedure in GP, normal controls (NC), and cataract patients (CP). Methods: The procedure was performed on 50 GP, 35 NC, and 27 CP. All subjects were examined with RE-PERG and SS-PERG and also with spectral domain optical coherence tomography and standard automated perimetry. Standard deviation of phase and amplitude value of 2ndH were correlated by means of one-way analysis of variance and Pearson correlation, with the mean deviation and pattern standard deviation assessed by standard automated perimetry and retinal nerve fiber layer and the ganglion cell complex thickness assessed by spectral domain optical coherence tomography. Receiver operating characteristics were calculated in cohort populations with and without cataract. Results: Standard deviation of phase of 2ndH was significantly higher in GP with respect to NC (P<0.001) and CP (P<0.001), and it correlated with retinal nerve fiber layer (r=-0.5, P<0.001) and ganglion cell complex (r=-0.6, P<0.001) defects in GP. Receiver operating characteristic evaluation showed higher specificity of RE-PERG (86.4%; area under the curve 0.93) with respect to SS-PERG (54.5%; area under the curve 0.68) in CP. Conclusion: RE-PERG may improve the specificity of SS-PERG in clinical practice in the discrimination of GP. Keywords: glaucoma, pattern electroretinogram, optical coherence tomography, ganglion cells, visual fieldMavilio ASisto DFerreri PCardascia NAlessio GDove Medical Pressarticleglaucomapattern electroretinogramoptical coherence tomographyganglion cellsvisual fieldOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 209-218 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	glaucoma pattern electroretinogram optical coherence tomography ganglion cells visual field Ophthalmology RE1-994
spellingShingle	glaucoma pattern electroretinogram optical coherence tomography ganglion cells visual field Ophthalmology RE1-994 Mavilio A Sisto D Ferreri P Cardascia N Alessio G RE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity
description	Alberto Mavilio,1 Dario Sisto,2 Paolo Ferreri,2 Nicola Cardascia,2 Giovanni Alessio2 1Social Health District, Glaucoma Center, Azienda Sanitaria Locale, Brindisi, 2Department of Ophthalmology and Otolaryngology, University of Bari, Bari, Italy Purpose: A significant variability of the second harmonic (2ndH) phase of steady-state pattern electroretinogram (SS-PERG) in intrasession retest has been recently described in glaucoma patients (GP), which has not been found in healthy subjects. To evaluate the reliability of phase variability in retest (a procedure called RE-PERG or REPERG) in the presence of cataract, which is known to affect standard PERG, we tested this procedure in GP, normal controls (NC), and cataract patients (CP). Methods: The procedure was performed on 50 GP, 35 NC, and 27 CP. All subjects were examined with RE-PERG and SS-PERG and also with spectral domain optical coherence tomography and standard automated perimetry. Standard deviation of phase and amplitude value of 2ndH were correlated by means of one-way analysis of variance and Pearson correlation, with the mean deviation and pattern standard deviation assessed by standard automated perimetry and retinal nerve fiber layer and the ganglion cell complex thickness assessed by spectral domain optical coherence tomography. Receiver operating characteristics were calculated in cohort populations with and without cataract. Results: Standard deviation of phase of 2ndH was significantly higher in GP with respect to NC (P<0.001) and CP (P<0.001), and it correlated with retinal nerve fiber layer (r=-0.5, P<0.001) and ganglion cell complex (r=-0.6, P<0.001) defects in GP. Receiver operating characteristic evaluation showed higher specificity of RE-PERG (86.4%; area under the curve 0.93) with respect to SS-PERG (54.5%; area under the curve 0.68) in CP. Conclusion: RE-PERG may improve the specificity of SS-PERG in clinical practice in the discrimination of GP. Keywords: glaucoma, pattern electroretinogram, optical coherence tomography, ganglion cells, visual field
format	article
author	Mavilio A Sisto D Ferreri P Cardascia N Alessio G
author_facet	Mavilio A Sisto D Ferreri P Cardascia N Alessio G
author_sort	Mavilio A
title	RE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity
title_short	RE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity
title_full	RE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity
title_fullStr	RE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity
title_full_unstemmed	RE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity
title_sort	re-perg, a new procedure for electrophysiologic diagnosis of glaucoma that may improve perg specificity
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/46bb1d875fd14648818446eace436491
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_version_	1718402706496815104

RE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity

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