Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD

Gaizhi Li,1 Kathryn Rossbach,2 Aixia Zhang,1 Penghong Liu,1 Kerang Zhang1 1Shanxi Medical University, Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2Independent researcher, Atlanta, GA, USA Background: Major depressive disorder (MDD) is a leading ps...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li G, Rossbach K, Zhang A, Liu P, Zhang K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Major Depressive Disorder Resting-state fMRI Precuneus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/46bb764459a9444c82221972c16350fa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:46bb764459a9444c82221972c16350fa
record_format	dspace
spelling	oai:doaj.org-article:46bb764459a9444c82221972c16350fa2021-12-02T02:20:35ZResting-state functional changes in the precuneus within first-episode drug-naive patients with MDD1178-2021https://doaj.org/article/46bb764459a9444c82221972c16350fa2018-08-01T00:00:00Zhttps://www.dovepress.com/resting-state-functional-changes-in-the-precuneus-within-first-episode-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Gaizhi Li,1 Kathryn Rossbach,2 Aixia Zhang,1 Penghong Liu,1 Kerang Zhang1 1Shanxi Medical University, Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2Independent researcher, Atlanta, GA, USA Background: Major depressive disorder (MDD) is a leading psychiatric disorder that has a lack of biomarkers for a diagnosis. Purpose: The objective of this study was to examine the structural and functional change in the precuneus within first-episode drug naive patients with MDD. Methods: Thirty-two first episode drug-naive patients with MDD and thirty healthy controls (HCs) were recruited in this study; the structural MRI and fMRI data were collected using the 3.0 T Trio Siemens System. All the patients were interviewed using the HAMD-17. Results: The difference between gray matter volume within the two groups was not observed. Results indicated that the low-frequency fluctuations (ALFF), fractional ALFF (fALFF) and regional homogeneity values of the precuneus within first-episode drug-naive patients with MDD were lower than the HCs. In addition, the fALFF value of the MDD was negatively and statistically significantly correlated with the HAMD-17 total score (P<0.05). Conclusion: The current study found abnormal activity of the precuneus at resting state in first-episode drug-naive patients with MDD, indicating that activity within the precuneus may be a potential biomarker for the diagnosis of MDD. Keywords: major depressive disorder, resting-state fMRI, precuneusLi GRossbach KZhang ALiu PZhang KDove Medical PressarticleMajor Depressive DisorderResting-state fMRIPrecuneusNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1991-1998 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Major Depressive Disorder Resting-state fMRI Precuneus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Major Depressive Disorder Resting-state fMRI Precuneus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li G Rossbach K Zhang A Liu P Zhang K Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD
description	Gaizhi Li,1 Kathryn Rossbach,2 Aixia Zhang,1 Penghong Liu,1 Kerang Zhang1 1Shanxi Medical University, Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2Independent researcher, Atlanta, GA, USA Background: Major depressive disorder (MDD) is a leading psychiatric disorder that has a lack of biomarkers for a diagnosis. Purpose: The objective of this study was to examine the structural and functional change in the precuneus within first-episode drug naive patients with MDD. Methods: Thirty-two first episode drug-naive patients with MDD and thirty healthy controls (HCs) were recruited in this study; the structural MRI and fMRI data were collected using the 3.0 T Trio Siemens System. All the patients were interviewed using the HAMD-17. Results: The difference between gray matter volume within the two groups was not observed. Results indicated that the low-frequency fluctuations (ALFF), fractional ALFF (fALFF) and regional homogeneity values of the precuneus within first-episode drug-naive patients with MDD were lower than the HCs. In addition, the fALFF value of the MDD was negatively and statistically significantly correlated with the HAMD-17 total score (P<0.05). Conclusion: The current study found abnormal activity of the precuneus at resting state in first-episode drug-naive patients with MDD, indicating that activity within the precuneus may be a potential biomarker for the diagnosis of MDD. Keywords: major depressive disorder, resting-state fMRI, precuneus
format	article
author	Li G Rossbach K Zhang A Liu P Zhang K
author_facet	Li G Rossbach K Zhang A Liu P Zhang K
author_sort	Li G
title	Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD
title_short	Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD
title_full	Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD
title_fullStr	Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD
title_full_unstemmed	Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD
title_sort	resting-state functional changes in the precuneus within first-episode drug-naive patients with mdd
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/46bb764459a9444c82221972c16350fa
work_keys_str_mv	AT lig restingstatefunctionalchangesintheprecuneuswithinfirstepisodedrugnaivepatientswithmdd AT rossbachk restingstatefunctionalchangesintheprecuneuswithinfirstepisodedrugnaivepatientswithmdd AT zhanga restingstatefunctionalchangesintheprecuneuswithinfirstepisodedrugnaivepatientswithmdd AT liup restingstatefunctionalchangesintheprecuneuswithinfirstepisodedrugnaivepatientswithmdd AT zhangk restingstatefunctionalchangesintheprecuneuswithinfirstepisodedrugnaivepatientswithmdd
_version_	1718402523637743616

Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD

Ejemplares similares