Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

As signalling molecules, bile acids (BAs) can affect metabolism, but due to detergent-like properties, BA levels must be tightly regulated. Here, Kim et al.show that RanBP2, a nucleoporin, maintains BA homoeostasis through SUMOylation of Small Heterodimer Partner (SHP), an orphan nuclear receptor.

Guardado en:

Detalles Bibliográficos
Autores principales:	Dong-Hyun Kim, Sanghoon Kwon, Sangwon Byun, Zhen Xiao, Sean Park, Shwu-Yuan Wu, Cheng-Ming Chiang, Byron Kemper, Jongsook Kim Kemper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/46bb7bc6983e422ca40abab92896dece
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:46bb7bc6983e422ca40abab92896dece
record_format	dspace
spelling	oai:doaj.org-article:46bb7bc6983e422ca40abab92896dece2021-12-02T15:33:50ZCritical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis10.1038/ncomms121792041-1723https://doaj.org/article/46bb7bc6983e422ca40abab92896dece2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12179https://doaj.org/toc/2041-1723As signalling molecules, bile acids (BAs) can affect metabolism, but due to detergent-like properties, BA levels must be tightly regulated. Here, Kim et al.show that RanBP2, a nucleoporin, maintains BA homoeostasis through SUMOylation of Small Heterodimer Partner (SHP), an orphan nuclear receptor.Dong-Hyun KimSanghoon KwonSangwon ByunZhen XiaoSean ParkShwu-Yuan WuCheng-Ming ChiangByron KemperJongsook Kim KemperNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dong-Hyun Kim Sanghoon Kwon Sangwon Byun Zhen Xiao Sean Park Shwu-Yuan Wu Cheng-Ming Chiang Byron Kemper Jongsook Kim Kemper Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis
description	As signalling molecules, bile acids (BAs) can affect metabolism, but due to detergent-like properties, BA levels must be tightly regulated. Here, Kim et al.show that RanBP2, a nucleoporin, maintains BA homoeostasis through SUMOylation of Small Heterodimer Partner (SHP), an orphan nuclear receptor.
format	article
author	Dong-Hyun Kim Sanghoon Kwon Sangwon Byun Zhen Xiao Sean Park Shwu-Yuan Wu Cheng-Ming Chiang Byron Kemper Jongsook Kim Kemper
author_facet	Dong-Hyun Kim Sanghoon Kwon Sangwon Byun Zhen Xiao Sean Park Shwu-Yuan Wu Cheng-Ming Chiang Byron Kemper Jongsook Kim Kemper
author_sort	Dong-Hyun Kim
title	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis
title_short	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis
title_full	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis
title_fullStr	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis
title_full_unstemmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis
title_sort	critical role of ranbp2-mediated sumoylation of small heterodimer partner in maintaining bile acid homeostasis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/46bb7bc6983e422ca40abab92896dece
work_keys_str_mv	AT donghyunkim criticalroleofranbp2mediatedsumoylationofsmallheterodimerpartnerinmaintainingbileacidhomeostasis AT sanghoonkwon criticalroleofranbp2mediatedsumoylationofsmallheterodimerpartnerinmaintainingbileacidhomeostasis AT sangwonbyun criticalroleofranbp2mediatedsumoylationofsmallheterodimerpartnerinmaintainingbileacidhomeostasis AT zhenxiao criticalroleofranbp2mediatedsumoylationofsmallheterodimerpartnerinmaintainingbileacidhomeostasis AT seanpark criticalroleofranbp2mediatedsumoylationofsmallheterodimerpartnerinmaintainingbileacidhomeostasis AT shwuyuanwu criticalroleofranbp2mediatedsumoylationofsmallheterodimerpartnerinmaintainingbileacidhomeostasis AT chengmingchiang criticalroleofranbp2mediatedsumoylationofsmallheterodimerpartnerinmaintainingbileacidhomeostasis AT byronkemper criticalroleofranbp2mediatedsumoylationofsmallheterodimerpartnerinmaintainingbileacidhomeostasis AT jongsookkimkemper criticalroleofranbp2mediatedsumoylationofsmallheterodimerpartnerinmaintainingbileacidhomeostasis
_version_	1718386957251248128

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

Ejemplares similares