Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study

This paper presents data from a transcutaneous vagus nerve stimulation experiment that point towards a blunted cardiac baroreceptor sensitivity (cBRS) in young males compared to females during electrical stimulation of the forearm and a rhythmic breathing task. Continuous electrocardiography, impeda...

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Autores principales:	Elisabeth Veiz, Susann-Kristin Kieslich, Julia Staab, Dirk Czesnik, Christoph Herrmann-Lingen, Thomas Meyer
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	spontaneous baroreceptor sensitivity transcutaneous vagus nerve stimulation sex differences heart rate variability nerve stimulation stress Medicine R
Acceso en línea:	https://doaj.org/article/46bbebcef734482fb8643c16b293ce49
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spelling	oai:doaj.org-article:46bbebcef734482fb8643c16b293ce492021-11-11T16:20:32ZMen Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study10.3390/ijerph1821111931660-46011661-7827https://doaj.org/article/46bbebcef734482fb8643c16b293ce492021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11193https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601This paper presents data from a transcutaneous vagus nerve stimulation experiment that point towards a blunted cardiac baroreceptor sensitivity (cBRS) in young males compared to females during electrical stimulation of the forearm and a rhythmic breathing task. Continuous electrocardiography, impedance cardiography and continuous blood-pressure recordings were assessed in a sex-matched cohort of twenty young healthy subjects. Electrical stimulation of the median nerve was conducted by using a threshold-tracking method combined with two rhythmic breathing tasks (0.1 and 0.2 Hz) before, during and after active or sham transcutaneous vagus nerve stimulation. Autonomic and hemodynamic parameters were calculated, and differences were analyzed by using linear mixed models and post hoc F-tests. None of the autonomic and hemodynamic parameters differed between the sham and active conditions. However, compared to females, male participants had an overall lower total cBRS independent of stimulation condition during nerve stimulation (females: 14.96 ± 5.67 ms/mmHg, males: 11.89 ± 3.24 ms/mmHg, <i>p</i> = 0.031) and rhythmic breathing at 0.2 Hz (females: 21.49 ± 8.47 ms/mmHg, males: 15.12 ± 5.70 ms/mmHg, <i>p</i> = 0.004). Whereas vagus nerve stimulation at the left inner tragus did not affect the efferent vagal control of the heart, we found similar patterns of baroreceptor sensitivity activation over the stimulation period in both sexes, which, however, significantly differed in their magnitude, with females showing an overall higher cBRS.Elisabeth VeizSusann-Kristin KieslichJulia StaabDirk CzesnikChristoph Herrmann-LingenThomas MeyerMDPI AGarticlespontaneous baroreceptor sensitivitytranscutaneous vagus nerve stimulationsex differencesheart rate variabilitynerve stimulationstressMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11193, p 11193 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spontaneous baroreceptor sensitivity transcutaneous vagus nerve stimulation sex differences heart rate variability nerve stimulation stress Medicine R
spellingShingle	spontaneous baroreceptor sensitivity transcutaneous vagus nerve stimulation sex differences heart rate variability nerve stimulation stress Medicine R Elisabeth Veiz Susann-Kristin Kieslich Julia Staab Dirk Czesnik Christoph Herrmann-Lingen Thomas Meyer Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study
description	This paper presents data from a transcutaneous vagus nerve stimulation experiment that point towards a blunted cardiac baroreceptor sensitivity (cBRS) in young males compared to females during electrical stimulation of the forearm and a rhythmic breathing task. Continuous electrocardiography, impedance cardiography and continuous blood-pressure recordings were assessed in a sex-matched cohort of twenty young healthy subjects. Electrical stimulation of the median nerve was conducted by using a threshold-tracking method combined with two rhythmic breathing tasks (0.1 and 0.2 Hz) before, during and after active or sham transcutaneous vagus nerve stimulation. Autonomic and hemodynamic parameters were calculated, and differences were analyzed by using linear mixed models and post hoc F-tests. None of the autonomic and hemodynamic parameters differed between the sham and active conditions. However, compared to females, male participants had an overall lower total cBRS independent of stimulation condition during nerve stimulation (females: 14.96 ± 5.67 ms/mmHg, males: 11.89 ± 3.24 ms/mmHg, <i>p</i> = 0.031) and rhythmic breathing at 0.2 Hz (females: 21.49 ± 8.47 ms/mmHg, males: 15.12 ± 5.70 ms/mmHg, <i>p</i> = 0.004). Whereas vagus nerve stimulation at the left inner tragus did not affect the efferent vagal control of the heart, we found similar patterns of baroreceptor sensitivity activation over the stimulation period in both sexes, which, however, significantly differed in their magnitude, with females showing an overall higher cBRS.
format	article
author	Elisabeth Veiz Susann-Kristin Kieslich Julia Staab Dirk Czesnik Christoph Herrmann-Lingen Thomas Meyer
author_facet	Elisabeth Veiz Susann-Kristin Kieslich Julia Staab Dirk Czesnik Christoph Herrmann-Lingen Thomas Meyer
author_sort	Elisabeth Veiz
title	Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study
title_short	Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study
title_full	Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study
title_fullStr	Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study
title_full_unstemmed	Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study
title_sort	men show reduced cardiac baroreceptor sensitivity during modestly painful electrical stimulation of the forearm: exploratory results from a sham-controlled crossover vagus nerve stimulation study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/46bbebcef734482fb8643c16b293ce49
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Men Show Reduced Cardiac Baroreceptor Sensitivity during Modestly Painful Electrical Stimulation of the Forearm: Exploratory Results from a Sham-Controlled Crossover Vagus Nerve Stimulation Study

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