PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE

Natural killer (NK) cells represent a lymphocyte subpopulation which is capable of contact cytolysis of virus-infected cells and tumor cells, being a source of cytokines which stimulate other immune cells and promote immune response. NK cell differentiation is connected with a consequent acquisition...

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Autores principales:	V. A. Mikhailova, K. L. Belyakova, S. A. Selkov, D. I. Sokolov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	nk cells differentiation pregnancy cell surface receptors cytokines uterine nk cells decidual nk cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/46bc5b749201442ab1dd3d583d7b2af2
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spelling	oai:doaj.org-article:46bc5b749201442ab1dd3d583d7b2af22021-11-18T08:03:45ZPECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE1563-06252313-741X10.15789/1563-0625-2017-1-19-26https://doaj.org/article/46bc5b749201442ab1dd3d583d7b2af22017-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1161https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XNatural killer (NK) cells represent a lymphocyte subpopulation which is capable of contact cytolysis of virus-infected cells and tumor cells, being a source of cytokines which stimulate other immune cells and promote immune response. NK cell differentiation is connected with a consequent acquisition of specific NK cell receptors by stem cells and formation of functional characteristics inherent to natural killer cells. The aim of this review was to describe the CD56dim and CD56bright populations of NK cells in the course of their differentiation. The authors describe NK surface receptors and expression of transcription factors at various steps of the NK differentiation. We present comparative characteristics of data concerning cytokines and cellular microenvironment influence upon NK cell differentiation, and examine a phenomenon of existing memory-like NK cells. Uterine NK cell differentiation is of special interest, since these cells represent a special NK cell population which prevails among decidual lymphocytes during pregnancy and participates in the process of placental formation and development. This review considers some features of uterine NK cell differentiation, taking into account a possibility of formation of this NK cell population from both peripheral blood NK pool, and in situ proliferation. Moreover, functional studies of the uterine NK cells allow to get closer to understanding the role of NK cells during pregnancy and abnormality of utero-placental bed regulation by NK cells in cases of pregnancy failure.V. A. MikhailovaK. L. BelyakovaS. A. SelkovD. I. SokolovSPb RAACIarticlenk cellsdifferentiationpregnancycell surface receptorscytokinesuterine nk cellsdecidual nk cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 1, Pp 19-26 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	nk cells differentiation pregnancy cell surface receptors cytokines uterine nk cells decidual nk cells Immunologic diseases. Allergy RC581-607
spellingShingle	nk cells differentiation pregnancy cell surface receptors cytokines uterine nk cells decidual nk cells Immunologic diseases. Allergy RC581-607 V. A. Mikhailova K. L. Belyakova S. A. Selkov D. I. Sokolov PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE
description	Natural killer (NK) cells represent a lymphocyte subpopulation which is capable of contact cytolysis of virus-infected cells and tumor cells, being a source of cytokines which stimulate other immune cells and promote immune response. NK cell differentiation is connected with a consequent acquisition of specific NK cell receptors by stem cells and formation of functional characteristics inherent to natural killer cells. The aim of this review was to describe the CD56dim and CD56bright populations of NK cells in the course of their differentiation. The authors describe NK surface receptors and expression of transcription factors at various steps of the NK differentiation. We present comparative characteristics of data concerning cytokines and cellular microenvironment influence upon NK cell differentiation, and examine a phenomenon of existing memory-like NK cells. Uterine NK cell differentiation is of special interest, since these cells represent a special NK cell population which prevails among decidual lymphocytes during pregnancy and participates in the process of placental formation and development. This review considers some features of uterine NK cell differentiation, taking into account a possibility of formation of this NK cell population from both peripheral blood NK pool, and in situ proliferation. Moreover, functional studies of the uterine NK cells allow to get closer to understanding the role of NK cells during pregnancy and abnormality of utero-placental bed regulation by NK cells in cases of pregnancy failure.
format	article
author	V. A. Mikhailova K. L. Belyakova S. A. Selkov D. I. Sokolov
author_facet	V. A. Mikhailova K. L. Belyakova S. A. Selkov D. I. Sokolov
author_sort	V. A. Mikhailova
title	PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE
title_short	PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE
title_full	PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE
title_fullStr	PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE
title_full_unstemmed	PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE
title_sort	peculiarities of nk cells differentiation: cd56dim and cd56bright nk cells at pregnancy and in non-pregnant state
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/46bc5b749201442ab1dd3d583d7b2af2
work_keys_str_mv	AT vamikhailova peculiaritiesofnkcellsdifferentiationcd56dimandcd56brightnkcellsatpregnancyandinnonpregnantstate AT klbelyakova peculiaritiesofnkcellsdifferentiationcd56dimandcd56brightnkcellsatpregnancyandinnonpregnantstate AT saselkov peculiaritiesofnkcellsdifferentiationcd56dimandcd56brightnkcellsatpregnancyandinnonpregnantstate AT disokolov peculiaritiesofnkcellsdifferentiationcd56dimandcd56brightnkcellsatpregnancyandinnonpregnantstate
_version_	1718422413399556096

PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE

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