Microbial Unmasking of Plant Glycosides

ABSTRACT The therapeutic potential of plants is widely recognized and harnessed in plant-based remedies and drug discovery. However, the factors that modulate the bioavailability and bioactivities of plant-derived phytochemicals are poorly understood. In a recent article in mBio, M. C. Theilmann et...

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Autores principales:	Kristen A. Biernat, Bo Li, Matthew R. Redinbo
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	enzymes gut microbiota plant glycosides Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/46be5645adfd41abbeaaed5bf677bcc7
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spelling	oai:doaj.org-article:46be5645adfd41abbeaaed5bf677bcc72021-11-15T15:53:26ZMicrobial Unmasking of Plant Glycosides10.1128/mBio.02433-172150-7511https://doaj.org/article/46be5645adfd41abbeaaed5bf677bcc72018-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02433-17https://doaj.org/toc/2150-7511ABSTRACT The therapeutic potential of plants is widely recognized and harnessed in plant-based remedies and drug discovery. However, the factors that modulate the bioavailability and bioactivities of plant-derived phytochemicals are poorly understood. In a recent article in mBio, M. C. Theilmann et al. (mBio 8:e01421-17, 2017, https://doi.org/10.1128/mBio.01421-17) describe how one gut microbe, Lactobacillus acidophilus, catalytically unwraps plant glucosides to make deglucosylated bioactive aglycones available to human tissues. They demonstrate that understanding the metabolism of plant glycosides by intestinal bacteria is essential to appreciating how bacteria manipulate the levels of bioactive plant metabolites in the human host.Kristen A. BiernatBo LiMatthew R. RedinboAmerican Society for Microbiologyarticleenzymesgut microbiotaplant glycosidesMicrobiologyQR1-502ENmBio, Vol 9, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	enzymes gut microbiota plant glycosides Microbiology QR1-502
spellingShingle	enzymes gut microbiota plant glycosides Microbiology QR1-502 Kristen A. Biernat Bo Li Matthew R. Redinbo Microbial Unmasking of Plant Glycosides
description	ABSTRACT The therapeutic potential of plants is widely recognized and harnessed in plant-based remedies and drug discovery. However, the factors that modulate the bioavailability and bioactivities of plant-derived phytochemicals are poorly understood. In a recent article in mBio, M. C. Theilmann et al. (mBio 8:e01421-17, 2017, https://doi.org/10.1128/mBio.01421-17) describe how one gut microbe, Lactobacillus acidophilus, catalytically unwraps plant glucosides to make deglucosylated bioactive aglycones available to human tissues. They demonstrate that understanding the metabolism of plant glycosides by intestinal bacteria is essential to appreciating how bacteria manipulate the levels of bioactive plant metabolites in the human host.
format	article
author	Kristen A. Biernat Bo Li Matthew R. Redinbo
author_facet	Kristen A. Biernat Bo Li Matthew R. Redinbo
author_sort	Kristen A. Biernat
title	Microbial Unmasking of Plant Glycosides
title_short	Microbial Unmasking of Plant Glycosides
title_full	Microbial Unmasking of Plant Glycosides
title_fullStr	Microbial Unmasking of Plant Glycosides
title_full_unstemmed	Microbial Unmasking of Plant Glycosides
title_sort	microbial unmasking of plant glycosides
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/46be5645adfd41abbeaaed5bf677bcc7
work_keys_str_mv	AT kristenabiernat microbialunmaskingofplantglycosides AT boli microbialunmaskingofplantglycosides AT matthewrredinbo microbialunmaskingofplantglycosides
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Microbial Unmasking of Plant Glycosides

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