Neuroprotection and acidosis induced by cortical spreading depression

Kenneth K Kwong, Suk-tak Chan Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA We read with interest the article “Cortical spreading depression produces a neuroprotective effect activ...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kwong KK, Chan ST
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	n/a Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/46c2173c7ed1470a8faa2acf736b0485
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:46c2173c7ed1470a8faa2acf736b0485
record_format	dspace
spelling	oai:doaj.org-article:46c2173c7ed1470a8faa2acf736b04852021-12-02T03:06:48ZNeuroprotection and acidosis induced by cortical spreading depression1178-2021https://doaj.org/article/46c2173c7ed1470a8faa2acf736b04852016-12-01T00:00:00Zhttps://www.dovepress.com/neuroprotection-and-acidosis-induced-by-cortical-spreading-depression-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Kenneth K Kwong, Suk-tak Chan Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA We read with interest the article “Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5” published in Neuropsychiatr Dis Treat by Viggiano et al.1 The authors showed that cerebral spreading depression (CSD) triggered uncoupling protein-5 (UCP-5),1 which had been reported to exert a long-term effect upon neuron protection.2 The result is another piece in CSD literature on modifying gene expressions to provide neuroprotection to subsequent ischemic episodes.3,4 Authors' replyGiovanni Messina1,2Emanuela Viggiano1,3Vincenzo Monda1Antonietta Messina1Fiorenzo Moscatelli2Anna Valenzano2Domenico Tafuri4Vincenzo De Luca5Giuseppe Cibelli2Marcellino Monda1 1Section of Human Physiology and Unit of Dietetic and Sport Medicine, Department of Experimental Medicine, Second University of Naples, Caserta, 2Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 3Department of Medicine, University of Padua, Padua, 4Department of Motor Sciences and Wellness, University of Naples “Parthenope,” Napoli, Italy; 5Department of Psychiatry, University of Toronto, Toronto, ON, Canada Thank you for the attention paid to our article entitled: “Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5”.1 We do agree that cerebral spreading depression (CSD)-induced acidosis is an intriguing aspect of the neuroprotection puzzle. It is well known that CSD is involved in the pathophysiology of migraine, cerebral ischemia, subarachnoid hemorrhage, and traumatic brain injury.2–7 View the original paper by Viggiano and colleagues. Kwong KKChan STDove Medical Pressarticlen/aNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 3191-3194 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	n/a Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	n/a Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kwong KK Chan ST Neuroprotection and acidosis induced by cortical spreading depression
description	Kenneth K Kwong, Suk-tak Chan Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA We read with interest the article “Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5” published in Neuropsychiatr Dis Treat by Viggiano et al.1 The authors showed that cerebral spreading depression (CSD) triggered uncoupling protein-5 (UCP-5),1 which had been reported to exert a long-term effect upon neuron protection.2 The result is another piece in CSD literature on modifying gene expressions to provide neuroprotection to subsequent ischemic episodes.3,4 Authors' replyGiovanni Messina1,2Emanuela Viggiano1,3Vincenzo Monda1Antonietta Messina1Fiorenzo Moscatelli2Anna Valenzano2Domenico Tafuri4Vincenzo De Luca5Giuseppe Cibelli2Marcellino Monda1 1Section of Human Physiology and Unit of Dietetic and Sport Medicine, Department of Experimental Medicine, Second University of Naples, Caserta, 2Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 3Department of Medicine, University of Padua, Padua, 4Department of Motor Sciences and Wellness, University of Naples “Parthenope,” Napoli, Italy; 5Department of Psychiatry, University of Toronto, Toronto, ON, Canada Thank you for the attention paid to our article entitled: “Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5”.1 We do agree that cerebral spreading depression (CSD)-induced acidosis is an intriguing aspect of the neuroprotection puzzle. It is well known that CSD is involved in the pathophysiology of migraine, cerebral ischemia, subarachnoid hemorrhage, and traumatic brain injury.2–7 View the original paper by Viggiano and colleagues.
format	article
author	Kwong KK Chan ST
author_facet	Kwong KK Chan ST
author_sort	Kwong KK
title	Neuroprotection and acidosis induced by cortical spreading depression
title_short	Neuroprotection and acidosis induced by cortical spreading depression
title_full	Neuroprotection and acidosis induced by cortical spreading depression
title_fullStr	Neuroprotection and acidosis induced by cortical spreading depression
title_full_unstemmed	Neuroprotection and acidosis induced by cortical spreading depression
title_sort	neuroprotection and acidosis induced by cortical spreading depression
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/46c2173c7ed1470a8faa2acf736b0485
work_keys_str_mv	AT kwongkk neuroprotectionandacidosisinducedbycorticalspreadingdepression AT chanst neuroprotectionandacidosisinducedbycorticalspreadingdepression
_version_	1718401912762531840

Neuroprotection and acidosis induced by cortical spreading depression

Ejemplares similares