Superpixel image segmentation of VISTA expression in colorectal cancer and its relationship to the tumoral microenvironment

Abstract Colorectal cancer (CRC) is the third most common cause of cancer related death in the United States (Jasperson et al. in Gastroenterology 138:2044–2058, https://doi.org/10.1053/j.gastro.2010.01.054 , 2010). Many studies have explored prognostic factors in CRC. Today, much focus has been pla...

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Autores principales:	Dongling Wu, Sean Hacking, Taisia Vitkovski, Mansoor Nasim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/46c2e6dd265e43d0991ba6566ddffd69
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spelling	oai:doaj.org-article:46c2e6dd265e43d0991ba6566ddffd692021-12-02T19:10:21ZSuperpixel image segmentation of VISTA expression in colorectal cancer and its relationship to the tumoral microenvironment10.1038/s41598-021-96417-12045-2322https://doaj.org/article/46c2e6dd265e43d0991ba6566ddffd692021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96417-1https://doaj.org/toc/2045-2322Abstract Colorectal cancer (CRC) is the third most common cause of cancer related death in the United States (Jasperson et al. in Gastroenterology 138:2044–2058, https://doi.org/10.1053/j.gastro.2010.01.054 , 2010). Many studies have explored prognostic factors in CRC. Today, much focus has been placed on the tumor microenvironment, including different immune cells and the extracellular matrix (ECM). The present study aims to evaluate the role of V-domain immunoglobulin suppressor of T cell activation (VISTA). We utilized QuPath for whole slides image analysis, performing superpixel image segmentation (SIS) on a 226 patient-cohort. High VISTA expression correlated with better disease-free survival (DFS), high tumor infiltrative lymphocyte, microsatellite instability, BRAF mutational status as well as lower tumor stage. High VISTA expression was also associated with mature stromal differentiation (SD). When cohorts were separated based on SD and MMR, only patients with immature SD and microsatellite stability were found to correlate VISTA expression with DFS. Considering raised VISTA expression is associated with improved survival, TILs, mature SD, and MMR in CRC; careful, well-designed clinical trials should be pursued which incorporate the underlying tumoral microenvironment.Dongling WuSean HackingTaisia VitkovskiMansoor NasimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dongling Wu Sean Hacking Taisia Vitkovski Mansoor Nasim Superpixel image segmentation of VISTA expression in colorectal cancer and its relationship to the tumoral microenvironment
description	Abstract Colorectal cancer (CRC) is the third most common cause of cancer related death in the United States (Jasperson et al. in Gastroenterology 138:2044–2058, https://doi.org/10.1053/j.gastro.2010.01.054 , 2010). Many studies have explored prognostic factors in CRC. Today, much focus has been placed on the tumor microenvironment, including different immune cells and the extracellular matrix (ECM). The present study aims to evaluate the role of V-domain immunoglobulin suppressor of T cell activation (VISTA). We utilized QuPath for whole slides image analysis, performing superpixel image segmentation (SIS) on a 226 patient-cohort. High VISTA expression correlated with better disease-free survival (DFS), high tumor infiltrative lymphocyte, microsatellite instability, BRAF mutational status as well as lower tumor stage. High VISTA expression was also associated with mature stromal differentiation (SD). When cohorts were separated based on SD and MMR, only patients with immature SD and microsatellite stability were found to correlate VISTA expression with DFS. Considering raised VISTA expression is associated with improved survival, TILs, mature SD, and MMR in CRC; careful, well-designed clinical trials should be pursued which incorporate the underlying tumoral microenvironment.
format	article
author	Dongling Wu Sean Hacking Taisia Vitkovski Mansoor Nasim
author_facet	Dongling Wu Sean Hacking Taisia Vitkovski Mansoor Nasim
author_sort	Dongling Wu
title	Superpixel image segmentation of VISTA expression in colorectal cancer and its relationship to the tumoral microenvironment
title_short	Superpixel image segmentation of VISTA expression in colorectal cancer and its relationship to the tumoral microenvironment
title_full	Superpixel image segmentation of VISTA expression in colorectal cancer and its relationship to the tumoral microenvironment
title_fullStr	Superpixel image segmentation of VISTA expression in colorectal cancer and its relationship to the tumoral microenvironment
title_full_unstemmed	Superpixel image segmentation of VISTA expression in colorectal cancer and its relationship to the tumoral microenvironment
title_sort	superpixel image segmentation of vista expression in colorectal cancer and its relationship to the tumoral microenvironment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/46c2e6dd265e43d0991ba6566ddffd69
work_keys_str_mv	AT donglingwu superpixelimagesegmentationofvistaexpressionincolorectalcanceranditsrelationshiptothetumoralmicroenvironment AT seanhacking superpixelimagesegmentationofvistaexpressionincolorectalcanceranditsrelationshiptothetumoralmicroenvironment AT taisiavitkovski superpixelimagesegmentationofvistaexpressionincolorectalcanceranditsrelationshiptothetumoralmicroenvironment AT mansoornasim superpixelimagesegmentationofvistaexpressionincolorectalcanceranditsrelationshiptothetumoralmicroenvironment
_version_	1718377082894942208

Superpixel image segmentation of VISTA expression in colorectal cancer and its relationship to the tumoral microenvironment

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