Effects of changes in end‐tidal PO2 and PCO2 on neural responses during rest and sustained attention

Abstract Impairments of cognitive function during alterations in arterial blood gases (e.g., high‐altitude hypoxia) may result from the disruption of neurovascular coupling; however, the link between changes in arterial blood gases, cognition, and cerebral blood flow (CBF) is poorly understood. To i...

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Autores principales:	Tom Bullock, Barry Giesbrecht, Andrew E. Beaudin, Bradley G. Goodyear, Marc J. Poulin
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	arterial blood gasses attention EEG neural oscillations neurovascular coupling P3 ERP Physiology QP1-981
Acceso en línea:	https://doaj.org/article/46c475b2f70e4462afe034b73e792704
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spelling	oai:doaj.org-article:46c475b2f70e4462afe034b73e7927042021-11-15T09:54:40ZEffects of changes in end‐tidal PO2 and PCO2 on neural responses during rest and sustained attention2051-817X10.14814/phy2.15106https://doaj.org/article/46c475b2f70e4462afe034b73e7927042021-11-01T00:00:00Zhttps://doi.org/10.14814/phy2.15106https://doaj.org/toc/2051-817XAbstract Impairments of cognitive function during alterations in arterial blood gases (e.g., high‐altitude hypoxia) may result from the disruption of neurovascular coupling; however, the link between changes in arterial blood gases, cognition, and cerebral blood flow (CBF) is poorly understood. To interrogate this link, we developed a multimodal empirical strategy capable of monitoring neural correlates of cognition and CBF simultaneously. Human participants performed a sustained attention task during hypoxia, hypercapnia, hypocapnia, and normoxia while electroencephalographic (EEG) activity and CBF (middle and posterior cerebral arteries; transcranial Doppler ultrasound) were simultaneously measured. The protocol alternated between rest and engaging in a visual target detection task that required participants to monitor a sequence of brief‐duration colored circles and detect infrequent, longer duration circles (targets). The target detection task was overlaid on a large, circular checkerboard that provided robust visual stimulation. Spectral decomposition and event‐related potential (ERP) analyses were applied to the EEG data to investigate spontaneous and task‐specific fluctuations in neural activity. There were three main sets of findings: (1) spontaneous alpha oscillatory activity was modulated as a function of arterial CO2 (hypocapnia and hypercapnia), (2) task‐related neurovascular coupling was disrupted by all arterial blood gas manipulations, and (3) changes in task‐related alpha and theta band activity and attenuation of the P3 ERP component amplitude were observed during hypocapnia. Since alpha and theta are linked with suppression of visual processing and executive control and P3 amplitude with task difficulty, these data suggest that transient arterial blood gas changes can modulate multiple stages of cognitive information processing.Tom BullockBarry GiesbrechtAndrew E. BeaudinBradley G. GoodyearMarc J. PoulinWileyarticlearterial blood gassesattentionEEGneural oscillationsneurovascular couplingP3 ERPPhysiologyQP1-981ENPhysiological Reports, Vol 9, Iss 21, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arterial blood gasses attention EEG neural oscillations neurovascular coupling P3 ERP Physiology QP1-981
spellingShingle	arterial blood gasses attention EEG neural oscillations neurovascular coupling P3 ERP Physiology QP1-981 Tom Bullock Barry Giesbrecht Andrew E. Beaudin Bradley G. Goodyear Marc J. Poulin Effects of changes in end‐tidal PO2 and PCO2 on neural responses during rest and sustained attention
description	Abstract Impairments of cognitive function during alterations in arterial blood gases (e.g., high‐altitude hypoxia) may result from the disruption of neurovascular coupling; however, the link between changes in arterial blood gases, cognition, and cerebral blood flow (CBF) is poorly understood. To interrogate this link, we developed a multimodal empirical strategy capable of monitoring neural correlates of cognition and CBF simultaneously. Human participants performed a sustained attention task during hypoxia, hypercapnia, hypocapnia, and normoxia while electroencephalographic (EEG) activity and CBF (middle and posterior cerebral arteries; transcranial Doppler ultrasound) were simultaneously measured. The protocol alternated between rest and engaging in a visual target detection task that required participants to monitor a sequence of brief‐duration colored circles and detect infrequent, longer duration circles (targets). The target detection task was overlaid on a large, circular checkerboard that provided robust visual stimulation. Spectral decomposition and event‐related potential (ERP) analyses were applied to the EEG data to investigate spontaneous and task‐specific fluctuations in neural activity. There were three main sets of findings: (1) spontaneous alpha oscillatory activity was modulated as a function of arterial CO2 (hypocapnia and hypercapnia), (2) task‐related neurovascular coupling was disrupted by all arterial blood gas manipulations, and (3) changes in task‐related alpha and theta band activity and attenuation of the P3 ERP component amplitude were observed during hypocapnia. Since alpha and theta are linked with suppression of visual processing and executive control and P3 amplitude with task difficulty, these data suggest that transient arterial blood gas changes can modulate multiple stages of cognitive information processing.
format	article
author	Tom Bullock Barry Giesbrecht Andrew E. Beaudin Bradley G. Goodyear Marc J. Poulin
author_facet	Tom Bullock Barry Giesbrecht Andrew E. Beaudin Bradley G. Goodyear Marc J. Poulin
author_sort	Tom Bullock
title	Effects of changes in end‐tidal PO2 and PCO2 on neural responses during rest and sustained attention
title_short	Effects of changes in end‐tidal PO2 and PCO2 on neural responses during rest and sustained attention
title_full	Effects of changes in end‐tidal PO2 and PCO2 on neural responses during rest and sustained attention
title_fullStr	Effects of changes in end‐tidal PO2 and PCO2 on neural responses during rest and sustained attention
title_full_unstemmed	Effects of changes in end‐tidal PO2 and PCO2 on neural responses during rest and sustained attention
title_sort	effects of changes in end‐tidal po2 and pco2 on neural responses during rest and sustained attention
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/46c475b2f70e4462afe034b73e792704
work_keys_str_mv	AT tombullock effectsofchangesinendtidalpo2andpco2onneuralresponsesduringrestandsustainedattention AT barrygiesbrecht effectsofchangesinendtidalpo2andpco2onneuralresponsesduringrestandsustainedattention AT andrewebeaudin effectsofchangesinendtidalpo2andpco2onneuralresponsesduringrestandsustainedattention AT bradleyggoodyear effectsofchangesinendtidalpo2andpco2onneuralresponsesduringrestandsustainedattention AT marcjpoulin effectsofchangesinendtidalpo2andpco2onneuralresponsesduringrestandsustainedattention
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Effects of changes in end‐tidal PO2 and PCO2 on neural responses during rest and sustained attention

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