First true initial ictal SPECT in partial epilepsy verified by electroencephalography

Jes&uacute;s Pastor1, Luis Dom&iacute;nguez-Gadea2, Rafael G Sola3, Virgilio Hernando3, Mar&iacute;a Luisa Meil&aacute;n4, Eva De Dios4, Jos&eacute; Luis Mart&iacute;nez-Chac&oacute;n4, Marcos Mart&iacute;nez51Clinical Neurophysiology;...

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Autores principales:	Jes&uacute;s Pastor, Luis Dom&iacute;nguez-Gadea, Rafael G Sola, Virgilio Hernando, Mar&iacute;a Luisa Meil&aacute;n, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/46c69485315043bfaa217fd9672f4b04
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spelling	oai:doaj.org-article:46c69485315043bfaa217fd9672f4b042021-12-02T03:24:49ZFirst true initial ictal SPECT in partial epilepsy verified by electroencephalography1176-63281178-2021https://doaj.org/article/46c69485315043bfaa217fd9672f4b042008-03-01T00:00:00Zhttp://www.dovepress.com/first-true-initial-ictal-spect-in-partial-epilepsy-verified-by-electro-a1014https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Jes&uacute;s Pastor1, Luis Dom&iacute;nguez-Gadea2, Rafael G Sola3, Virgilio Hernando3, Mar&iacute;a Luisa Meil&aacute;n4, Eva De Dios4, Jos&eacute; Luis Mart&iacute;nez-Chac&oacute;n4, Marcos Mart&iacute;nez51Clinical Neurophysiology; 2Nuclear Medicine; 3Neurosurgery; 4Anaesthesiology and Reanimation; Hospital Universitario &ldquo;La Princesa&rdquo;, Madrid, Spain; 5Anaesthesiology and Reanimation, Cardiovascular Unit of Adults, Hospital Ram&oacute;n y Cajal, Madrid, SpainAbstract: Drug-resistant epilepsy can sometimes be treated by surgery. In these cases, an accurate identification of the epileptogenic area must be addressed before resection. Ictal SPECT is one of the presurgical evaluations that can be performed, but usually, the increase in the regional cerebral perfusion observed is produced by diffusion of ictal activity. Here we describe a patient studied with v-EEG and foramen ovale electrodes that suffered a seizure after intravenous infusion of etomidate. The sequence of etomidate administration, followed by radiotracer and seizure was good enough for us to suspect that a true initial ictal SPECT was observed. We have implemented a kinetic model with four compartments, previously described (Andersen 1989), in order to estimate the fraction of hydrophilic radiotracer in the brain during the pre-ictal and ictal periods. This model has shown that the fraction of hydrophilic radiotracer during the seizure into the brain would be between 18.9% and 42.3% of total infused. We show the first true initial ictal SPECT demonstrated by bioelectrical recordings of the brain activity, obtained by a correct succession of events and compatible with theoretical data obtained from the kinetic model.Keywords: etomidate, foramen ovale electrodes, mathematical model, temporal lobe epilepsy Jes&uacute;s PastorLuis Dom&iacute;nguez-GadeaRafael G SolaVirgilio HernandoMar&iacute;a Luisa Meil&aacute;net alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 305-309 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jes&uacute;s Pastor Luis Dom&iacute;nguez-Gadea Rafael G Sola Virgilio Hernando Mar&iacute;a Luisa Meil&aacute;n et al First true initial ictal SPECT in partial epilepsy verified by electroencephalography
description	Jes&uacute;s Pastor1, Luis Dom&iacute;nguez-Gadea2, Rafael G Sola3, Virgilio Hernando3, Mar&iacute;a Luisa Meil&aacute;n4, Eva De Dios4, Jos&eacute; Luis Mart&iacute;nez-Chac&oacute;n4, Marcos Mart&iacute;nez51Clinical Neurophysiology; 2Nuclear Medicine; 3Neurosurgery; 4Anaesthesiology and Reanimation; Hospital Universitario &ldquo;La Princesa&rdquo;, Madrid, Spain; 5Anaesthesiology and Reanimation, Cardiovascular Unit of Adults, Hospital Ram&oacute;n y Cajal, Madrid, SpainAbstract: Drug-resistant epilepsy can sometimes be treated by surgery. In these cases, an accurate identification of the epileptogenic area must be addressed before resection. Ictal SPECT is one of the presurgical evaluations that can be performed, but usually, the increase in the regional cerebral perfusion observed is produced by diffusion of ictal activity. Here we describe a patient studied with v-EEG and foramen ovale electrodes that suffered a seizure after intravenous infusion of etomidate. The sequence of etomidate administration, followed by radiotracer and seizure was good enough for us to suspect that a true initial ictal SPECT was observed. We have implemented a kinetic model with four compartments, previously described (Andersen 1989), in order to estimate the fraction of hydrophilic radiotracer in the brain during the pre-ictal and ictal periods. This model has shown that the fraction of hydrophilic radiotracer during the seizure into the brain would be between 18.9% and 42.3% of total infused. We show the first true initial ictal SPECT demonstrated by bioelectrical recordings of the brain activity, obtained by a correct succession of events and compatible with theoretical data obtained from the kinetic model.Keywords: etomidate, foramen ovale electrodes, mathematical model, temporal lobe epilepsy
format	article
author	Jes&uacute;s Pastor Luis Dom&iacute;nguez-Gadea Rafael G Sola Virgilio Hernando Mar&iacute;a Luisa Meil&aacute;n et al
author_facet	Jes&uacute;s Pastor Luis Dom&iacute;nguez-Gadea Rafael G Sola Virgilio Hernando Mar&iacute;a Luisa Meil&aacute;n et al
author_sort	Jes&uacute;s Pastor
title	First true initial ictal SPECT in partial epilepsy verified by electroencephalography
title_short	First true initial ictal SPECT in partial epilepsy verified by electroencephalography
title_full	First true initial ictal SPECT in partial epilepsy verified by electroencephalography
title_fullStr	First true initial ictal SPECT in partial epilepsy verified by electroencephalography
title_full_unstemmed	First true initial ictal SPECT in partial epilepsy verified by electroencephalography
title_sort	first true initial ictal spect in partial epilepsy verified by electroencephalography
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/46c69485315043bfaa217fd9672f4b04
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_version_	1718401790718771200

First true initial ictal SPECT in partial epilepsy verified by electroencephalography

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