The use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats

Objectives. Rapid development and widespread application of different types of nanoparticles (NPs) may result in increased exposure of humans and animals to NPs. Recently, reproductive toxicity due to NP exposure has become a major component of risk assessment. Current data have suggested that NPs m...

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Autores principales:	Scsukova Sona, Mlynarcikova Alzbeta Bujnakova, Rollerova Eva
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	polymeric nanoparticles peg-b-pla titanium dioxide ovary progesterone estradiol reproductive toxicity Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/46ca62255454478f8e821f454ccfc107
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id	oai:doaj.org-article:46ca62255454478f8e821f454ccfc107
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spelling	oai:doaj.org-article:46ca62255454478f8e821f454ccfc1072021-12-02T16:41:14ZThe use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats1336-032910.2478/enr-2020-0007https://doaj.org/article/46ca62255454478f8e821f454ccfc1072020-01-01T00:00:00Zhttps://doi.org/10.2478/enr-2020-0007https://doaj.org/toc/1336-0329Objectives. Rapid development and widespread application of different types of nanoparticles (NPs) may result in increased exposure of humans and animals to NPs. Recently, reproductive toxicity due to NP exposure has become a major component of risk assessment. Current data have suggested that NPs may pose adverse effects on male and female reproductive health by altering normal testis and ovarian structure, and sex hormone levels. To detect possible alterations in steroidogenesis in adult and infantile rats following neonatal exposure to polymeric poly(ethylene glycol)-block-polylactide methyl ether (PEG-b-PLA) or titanium dioxide (TiO2) NPs, whole ovary cultures were used.Scsukova SonaMlynarcikova Alzbeta BujnakovaRollerova EvaSciendoarticlepolymeric nanoparticlespeg-b-platitanium dioxideovaryprogesteroneestradiolreproductive toxicityDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 54, Iss 1, Pp 53-63 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymeric nanoparticles peg-b-pla titanium dioxide ovary progesterone estradiol reproductive toxicity Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	polymeric nanoparticles peg-b-pla titanium dioxide ovary progesterone estradiol reproductive toxicity Diseases of the endocrine glands. Clinical endocrinology RC648-665 Scsukova Sona Mlynarcikova Alzbeta Bujnakova Rollerova Eva The use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats
description	Objectives. Rapid development and widespread application of different types of nanoparticles (NPs) may result in increased exposure of humans and animals to NPs. Recently, reproductive toxicity due to NP exposure has become a major component of risk assessment. Current data have suggested that NPs may pose adverse effects on male and female reproductive health by altering normal testis and ovarian structure, and sex hormone levels. To detect possible alterations in steroidogenesis in adult and infantile rats following neonatal exposure to polymeric poly(ethylene glycol)-block-polylactide methyl ether (PEG-b-PLA) or titanium dioxide (TiO2) NPs, whole ovary cultures were used.
format	article
author	Scsukova Sona Mlynarcikova Alzbeta Bujnakova Rollerova Eva
author_facet	Scsukova Sona Mlynarcikova Alzbeta Bujnakova Rollerova Eva
author_sort	Scsukova Sona
title	The use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats
title_short	The use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats
title_full	The use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats
title_fullStr	The use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats
title_full_unstemmed	The use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats
title_sort	use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in wistar rats
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/46ca62255454478f8e821f454ccfc107
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The use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats

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