Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation

Osteoarthritis results from the progressive destruction of cartilage matrix. Here, Kim et al. identify tankyrase as a regulator of cartilage matrix anabolism, and find that tankyrase inhibition, by preventing SOX9 PARylation, protects from cartilage destruction in a mouse model of osteoarthritis.

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Autores principales:	Sukyeong Kim, Sangbin Han, Yeongjae Kim, Hyeon-Seop Kim, Young-Ran Gu, Donghyun Kang, Yongsik Cho, Hyeonkyeong Kim, Jeeyeon Lee, Yeyoung Seo, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang, Jin-Hong Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/46d0bdc0020348988c792848c52d62dc
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spelling	oai:doaj.org-article:46d0bdc0020348988c792848c52d62dc2021-12-02T16:58:17ZTankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation10.1038/s41467-019-12910-22041-1723https://doaj.org/article/46d0bdc0020348988c792848c52d62dc2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12910-2https://doaj.org/toc/2041-1723Osteoarthritis results from the progressive destruction of cartilage matrix. Here, Kim et al. identify tankyrase as a regulator of cartilage matrix anabolism, and find that tankyrase inhibition, by preventing SOX9 PARylation, protects from cartilage destruction in a mouse model of osteoarthritis.Sukyeong KimSangbin HanYeongjae KimHyeon-Seop KimYoung-Ran GuDonghyun KangYongsik ChoHyeonkyeong KimJeeyeon LeeYeyoung SeoMoon Jong ChangChong Bum ChangSeung-Baik KangJin-Hong KimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sukyeong Kim Sangbin Han Yeongjae Kim Hyeon-Seop Kim Young-Ran Gu Donghyun Kang Yongsik Cho Hyeonkyeong Kim Jeeyeon Lee Yeyoung Seo Moon Jong Chang Chong Bum Chang Seung-Baik Kang Jin-Hong Kim Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
description	Osteoarthritis results from the progressive destruction of cartilage matrix. Here, Kim et al. identify tankyrase as a regulator of cartilage matrix anabolism, and find that tankyrase inhibition, by preventing SOX9 PARylation, protects from cartilage destruction in a mouse model of osteoarthritis.
format	article
author	Sukyeong Kim Sangbin Han Yeongjae Kim Hyeon-Seop Kim Young-Ran Gu Donghyun Kang Yongsik Cho Hyeonkyeong Kim Jeeyeon Lee Yeyoung Seo Moon Jong Chang Chong Bum Chang Seung-Baik Kang Jin-Hong Kim
author_facet	Sukyeong Kim Sangbin Han Yeongjae Kim Hyeon-Seop Kim Young-Ran Gu Donghyun Kang Yongsik Cho Hyeonkyeong Kim Jeeyeon Lee Yeyoung Seo Moon Jong Chang Chong Bum Chang Seung-Baik Kang Jin-Hong Kim
author_sort	Sukyeong Kim
title	Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
title_short	Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
title_full	Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
title_fullStr	Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
title_full_unstemmed	Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
title_sort	tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on sox9 parylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/46d0bdc0020348988c792848c52d62dc
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Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation

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