The Multifunctional Fungal Ergosterol
ABSTRACT The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and t...
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American Society for Microbiology
2018
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oai:doaj.org-article:46d258ffd35449c59a9f479d317f135e2021-11-15T15:58:21ZThe Multifunctional Fungal Ergosterol10.1128/mBio.01755-182150-7511https://doaj.org/article/46d258ffd35449c59a9f479d317f135e2018-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01755-18https://doaj.org/toc/2150-7511ABSTRACT The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtually all steps of its biosynthetic process are potential drug targets. In combination, those two reports strongly indicate that the biological relevance of ergosterol is broader than the current literature suggests.Marcio L. RodriguesAmerican Society for MicrobiologyarticleCandida albicansSaccharomyces cerevisiaeantifungal agentsergosterolfungiimmunityMicrobiologyQR1-502ENmBio, Vol 9, Iss 5 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Candida albicans Saccharomyces cerevisiae antifungal agents ergosterol fungi immunity Microbiology QR1-502 |
| spellingShingle |
Candida albicans Saccharomyces cerevisiae antifungal agents ergosterol fungi immunity Microbiology QR1-502 Marcio L. Rodrigues The Multifunctional Fungal Ergosterol |
| description |
ABSTRACT The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtually all steps of its biosynthetic process are potential drug targets. In combination, those two reports strongly indicate that the biological relevance of ergosterol is broader than the current literature suggests. |
| format |
article |
| author |
Marcio L. Rodrigues |
| author_facet |
Marcio L. Rodrigues |
| author_sort |
Marcio L. Rodrigues |
| title |
The Multifunctional Fungal Ergosterol |
| title_short |
The Multifunctional Fungal Ergosterol |
| title_full |
The Multifunctional Fungal Ergosterol |
| title_fullStr |
The Multifunctional Fungal Ergosterol |
| title_full_unstemmed |
The Multifunctional Fungal Ergosterol |
| title_sort |
multifunctional fungal ergosterol |
| publisher |
American Society for Microbiology |
| publishDate |
2018 |
| url |
https://doaj.org/article/46d258ffd35449c59a9f479d317f135e |
| work_keys_str_mv |
AT marciolrodrigues themultifunctionalfungalergosterol AT marciolrodrigues multifunctionalfungalergosterol |
| _version_ |
1718427025426874368 |