Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats

Mohammad Bagher Khorrami,1,2 Hamid Reza Sadeghnia,3 Alireza Pasdar,1,4 Majid Ghayour-Mobarhan,5 Bamdad Riahi-Zanjani,6 Alireza Hashemzadeh,7 Mohammad Zare,2 Majid Darroudi8 1Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2...

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Autores principales:	Khorrami MB, Sadeghnia HR, Pasdar A, Ghayour-Mobarhan M, Riahi-Zanjani B, Hashemzadeh A, Zareh M, Darroudi M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Cerium oxide nanoparticles pullulan toxicity antioxidant rat Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/46d587f404954b619b21bf483d9b1226
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spelling	oai:doaj.org-article:46d587f404954b619b21bf483d9b12262021-12-02T10:04:21ZAntioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats1178-2013https://doaj.org/article/46d587f404954b619b21bf483d9b12262019-04-01T00:00:00Zhttps://www.dovepress.com/antioxidant-and-toxicity-studies-of-biosynthesized-cerium-oxide-nanopa-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mohammad Bagher Khorrami,1,2 Hamid Reza Sadeghnia,3 Alireza Pasdar,1,4 Majid Ghayour-Mobarhan,5 Bamdad Riahi-Zanjani,6 Alireza Hashemzadeh,7 Mohammad Zare,2 Majid Darroudi8 1Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2Social Security Organization, 17th Shahrivar Hospital, Mashhad, Iran; 3Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 4Division of Applied Medicine, Medical School, University of Aberdeen, Aberdeen, UK; 5Biochemistry of Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 6Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 7NanoBioEletrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran; 8Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Purpose: The purpose of this study was to investigate the acute toxic potential of cerium oxide nanoparticles (CNPs) synthesized by pullulan in adult male Wistar rats. Patients and methods: Thirty male Wistar rats randomly were divided into five experimental groups of six animals each. The animals were received 50, 100, 200, and 400 mg/kg CNPs for 14 consecutive days. At the end of the experiment, the rats were euthanized and histopathological evaluation of the liver and renal tissues, as well ass, the markers of serum oxidative stress including thiobarbituric acid reactive substances, total sulfhydryl content, and antioxidant capacity (using ferric reducing/antioxidant power assay) were assessed. Hematological parameters and the activity of liver function enzymes were also measured. Results: The results of this study showed that CNPs caused no significant changes in the activity of liver enzymes, hepatic and renal histopathology and hematological parameters, while significantly improved serum redox status. Conclusion: Acute administration of pullulan-mediated CNPs is safe and possess antioxidant activity. Keywords: green synthesis, metal oxide, sol-gel, toxicology, radical scavengerKhorrami MBSadeghnia HRPasdar AGhayour-Mobarhan MRiahi-Zanjani BHashemzadeh AZareh MDarroudi MDove Medical PressarticleCerium oxide nanoparticlespullulantoxicityantioxidantratMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 2915-2926 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cerium oxide nanoparticles pullulan toxicity antioxidant rat Medicine (General) R5-920
spellingShingle	Cerium oxide nanoparticles pullulan toxicity antioxidant rat Medicine (General) R5-920 Khorrami MB Sadeghnia HR Pasdar A Ghayour-Mobarhan M Riahi-Zanjani B Hashemzadeh A Zareh M Darroudi M Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats
description	Mohammad Bagher Khorrami,1,2 Hamid Reza Sadeghnia,3 Alireza Pasdar,1,4 Majid Ghayour-Mobarhan,5 Bamdad Riahi-Zanjani,6 Alireza Hashemzadeh,7 Mohammad Zare,2 Majid Darroudi8 1Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2Social Security Organization, 17th Shahrivar Hospital, Mashhad, Iran; 3Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 4Division of Applied Medicine, Medical School, University of Aberdeen, Aberdeen, UK; 5Biochemistry of Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 6Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 7NanoBioEletrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran; 8Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Purpose: The purpose of this study was to investigate the acute toxic potential of cerium oxide nanoparticles (CNPs) synthesized by pullulan in adult male Wistar rats. Patients and methods: Thirty male Wistar rats randomly were divided into five experimental groups of six animals each. The animals were received 50, 100, 200, and 400 mg/kg CNPs for 14 consecutive days. At the end of the experiment, the rats were euthanized and histopathological evaluation of the liver and renal tissues, as well ass, the markers of serum oxidative stress including thiobarbituric acid reactive substances, total sulfhydryl content, and antioxidant capacity (using ferric reducing/antioxidant power assay) were assessed. Hematological parameters and the activity of liver function enzymes were also measured. Results: The results of this study showed that CNPs caused no significant changes in the activity of liver enzymes, hepatic and renal histopathology and hematological parameters, while significantly improved serum redox status. Conclusion: Acute administration of pullulan-mediated CNPs is safe and possess antioxidant activity. Keywords: green synthesis, metal oxide, sol-gel, toxicology, radical scavenger
format	article
author	Khorrami MB Sadeghnia HR Pasdar A Ghayour-Mobarhan M Riahi-Zanjani B Hashemzadeh A Zareh M Darroudi M
author_facet	Khorrami MB Sadeghnia HR Pasdar A Ghayour-Mobarhan M Riahi-Zanjani B Hashemzadeh A Zareh M Darroudi M
author_sort	Khorrami MB
title	Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats
title_short	Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats
title_full	Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats
title_fullStr	Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats
title_full_unstemmed	Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats
title_sort	antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/46d587f404954b619b21bf483d9b1226
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Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats

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